Increased
dendritic spine densities on cortical projection neurons in autism spectrum disorders.
Single spine stimulation by two-photon activation (uncaging) of glutamate has revealed that the uncaging-evoked AMPA-R current through the stimulated spine is strongly correlated with spine head size, which supports the hypothesis that
dendritic spine size is a key determinant of synaptic efficacy.
Alot et al., "Influence of matrix metalloproteinase MMP-9 on
dendritic spine morphology," Journal of Cell Science, vol.
Kiwifruit Increased
Dendritic Spine Density in Pb-Exposed Rats.
(54,58-60) Cocaine increased
dendritic spine density and dendritic branches in the NAc shell, medium spiny neurons, mPFC pyramidal neurons, and VTA dopaminergic neurons (Table 3).
For proteins, significant gene ontologies were
dendritic spine morphogenesis and the nitric oxide biosynthetic process with
dendritic spine morphogenesis being highly significant.
Dopamine depletion of the prefrontal cortex induces
dendritic spine loss: reversal by atypical antipsychotic drug treatment.
Morris water maze test was evaluated; immunofluorescent histochemistry was used to identify astrocytes activation, and immunofluorescent
dendritic spine analysis was used to identify the
dendritic spines morphological characteristics expression levels in hippocampus.
An early computational model of calcium influx, diffusion, and buffering in a single cortical
dendritic spine compared the calcium amplitudes occurring in response to differing stimulation frequencies (Gamble and Koch, 1987).
Receptors [GABA.sub.A] are found on
dendritic spine heads and necks [5].
Receptors on the postsynaptic neuron located on the
dendritic spine of the synapse bind the neurotransmitters, causing local depolarization of the membrane at these junctions.
Reduction of
Dendritic Spine Density in Diabetic Rat.
