2002) Long-term dendritic spine
stability in the adult cortex.
54,58-60) Cocaine increased dendritic spine
density and dendritic branches in the NAc shell, medium spiny neurons, mPFC pyramidal neurons, and VTA dopaminergic neurons (Table 3).
For proteins, significant gene ontologies were dendritic spine
morphogenesis and the nitric oxide biosynthetic process with dendritic spine
morphogenesis being highly significant.
Dopamine depletion of the prefrontal cortex induces dendritic spine
loss: reversal by atypical antipsychotic drug treatment.
Morris water maze test was evaluated; immunofluorescent histochemistry was used to identify astrocytes activation, and immunofluorescent dendritic spine
analysis was used to identify the dendritic spines
morphological characteristics expression levels in hippocampus.
An early computational model of calcium influx, diffusion, and buffering in a single cortical dendritic spine
compared the calcium amplitudes occurring in response to differing stimulation frequencies (Gamble and Koch, 1987).
Receptors on the postsynaptic neuron located on the dendritic spine
of the synapse bind the neurotransmitters, causing local depolarization of the membrane at these junctions.
The study has begun to investigate the effects of dendritic spine
changes in the sensory and motor systems after SCI/D, which could help identify ways to therapeutically target pain and spasticity.
mGluR5 knockout mice display increased dendritic spine
One target gene of CREB encodes a molecule, brain-derived neurotrophic factor (BDNF), which plays an important role in the regulation of synaptic plasticity and dendritic spine
structure (Minichiello 2009; Poo 2001; Tao et al.
An activity-induced microRNA controls dendritic spine
formation by regulating Racl-PAK signaling.
A dendritic spine
is a small membranous protrusion from a neuron's dendrite that typically receives input form a single synapse of an axon, stores synaptic strength, and helps transmit electrical signals to the neuron's cell body.