2002) Long-term
dendritic spine stability in the adult cortex.
54,58-60) Cocaine increased
dendritic spine density and dendritic branches in the NAc shell, medium spiny neurons, mPFC pyramidal neurons, and VTA dopaminergic neurons (Table 3).
For proteins, significant gene ontologies were
dendritic spine morphogenesis and the nitric oxide biosynthetic process with
dendritic spine morphogenesis being highly significant.
Dopamine depletion of the prefrontal cortex induces
dendritic spine loss: reversal by atypical antipsychotic drug treatment.
Morris water maze test was evaluated; immunofluorescent histochemistry was used to identify astrocytes activation, and immunofluorescent
dendritic spine analysis was used to identify the
dendritic spines morphological characteristics expression levels in hippocampus.
An early computational model of calcium influx, diffusion, and buffering in a single cortical
dendritic spine compared the calcium amplitudes occurring in response to differing stimulation frequencies (Gamble and Koch, 1987).
Receptors on the postsynaptic neuron located on the
dendritic spine of the synapse bind the neurotransmitters, causing local depolarization of the membrane at these junctions.
The study has begun to investigate the effects of
dendritic spine changes in the sensory and motor systems after SCI/D, which could help identify ways to therapeutically target pain and spasticity.
mGluR5 knockout mice display increased
dendritic spine densities.
One target gene of CREB encodes a molecule, brain-derived neurotrophic factor (BDNF), which plays an important role in the regulation of synaptic plasticity and
dendritic spine structure (Minichiello 2009; Poo 2001; Tao et al.
An activity-induced microRNA controls
dendritic spine formation by regulating Racl-PAK signaling.
A
dendritic spine is a small membranous protrusion from a neuron's dendrite that typically receives input form a single synapse of an axon, stores synaptic strength, and helps transmit electrical signals to the neuron's cell body.
