Increased dendritic spine
densities on cortical projection neurons in autism spectrum disorders.
Single spine stimulation by two-photon activation (uncaging) of glutamate has revealed that the uncaging-evoked AMPA-R current through the stimulated spine is strongly correlated with spine head size, which supports the hypothesis that dendritic spine
size is a key determinant of synaptic efficacy.
Alot et al., "Influence of matrix metalloproteinase MMP-9 on dendritic spine
morphology," Journal of Cell Science, vol.
Kiwifruit Increased Dendritic Spine
Density in Pb-Exposed Rats.
(54,58-60) Cocaine increased dendritic spine
density and dendritic branches in the NAc shell, medium spiny neurons, mPFC pyramidal neurons, and VTA dopaminergic neurons (Table 3).
For proteins, significant gene ontologies were dendritic spine
morphogenesis and the nitric oxide biosynthetic process with dendritic spine
morphogenesis being highly significant.
Dopamine depletion of the prefrontal cortex induces dendritic spine
loss: reversal by atypical antipsychotic drug treatment.
Morris water maze test was evaluated; immunofluorescent histochemistry was used to identify astrocytes activation, and immunofluorescent dendritic spine
analysis was used to identify the dendritic spines
morphological characteristics expression levels in hippocampus.
An early computational model of calcium influx, diffusion, and buffering in a single cortical dendritic spine
compared the calcium amplitudes occurring in response to differing stimulation frequencies (Gamble and Koch, 1987).
Receptors [GABA.sub.A] are found on dendritic spine
heads and necks .
Receptors on the postsynaptic neuron located on the dendritic spine
of the synapse bind the neurotransmitters, causing local depolarization of the membrane at these junctions.
Reduction of Dendritic Spine
Density in Diabetic Rat.