Langerhans’ cell

(redirected from dendritic reticulum cell)

Langerhans’ cell

A group of conditions characterised by proliferation of Langerhans cells, a lymphoreticular cell. Langerhans cell aggregates are nodular—especially in the lungs—and variably accompanied by eosinophils, foamy cells, neutrophils and fibrosis.

Prognosis
Good if limited to a single system. Multi-system involvement carries a 10–20% mortality due to organ failure; 50–60% have chronic disease, 30–40% have long-term clinical remission.

Langerhans cell histiocytosis types 
Pulmonary LCH
A lesion virtually exclusive to cigarette smokers, which is a form of smoking-related interstitial lung disease. Smoking cessation may lead to reversal of changes or evolution to pulmonary fibrosis and pulmonary hypertension. 

Unifocal LCH
Eosinophilic granuloma; solitary bone involvement—A lesion of younger patients that may affect any bone (except in hands and feet), most commonly the cranial vault, jaw, humerus, rib and femur.
 
Imaging
Mimics Ewing sarcoma.
 
Treatment
Curettage.
 
Prognosis
Excellent.
 
Multifocal unisystem LCH
Hand-Schüller-Christian disease, polyostotic eosinophilic granuloma; multiple bone involvement—A lesion that may affect the skin, accompanied by proptosis, diabetes insipidus or chronic otitis media or combination thereof, marked by a chronic course with waxing and waning symptoms.
 
Prognosis
Relatively good.
 
Multifocal multisystem LCH
Letterer-Siwe disease; multiple organ involvement—A lesion that affects bone, lung and skin; while histologically indistinct, it is more aggressive than the other forms.
 
Prognosis
Poor if < 18 months at time of diagnosis, haemorrhagic skin lesions, hepatomegaly, anaemia, thrombocytopenia, bone marrow involvement.
References in periodicals archive ?
A primary lymph node malignancy with features suggestive of dendritic reticulum cell differentiation.
Other synonyms include reticulum cell sarcoma/tumor and dendritic reticulum cell sarcoma/tumor.
In this article, we describe a new case of dendritic reticulum cell sarcoma in the oral cavity--one that arose in the tonsil.
Based on these findings, we established the diagnosis of dendritic reticulum cell sarcoma of the tonsil.
Inflammatory pseudotumor of the liver: evidence for follicular dendritic reticulum cell proliferation associated with clonal Epstein-Barr virus.
Selective visualization of human dendritic reticulum cells in reactive lymphoid follicles by the immunohistochemical demonstration of the subunit A of factor XIII (F-XIIIa).
They reported 4 cases of nodal spindle cell neoplasms with features suggestive of dendritic reticulum cell differentiation based on the expression of a dendritic reticulum cell marker (R4/23) and the presence of long, complex cytoplasmic extensions and numerous macula adherens-type cell junctions.
Some well-known examples include the expression of vimentin in stromal cells, the expression of keratin in a subset of dendritic reticulum cells in lymph nodes, or the expression of S100 protein in a rare lymphoid cell or macrophage in lymph nodes.
Human dendritic reticulum cells of lymphoid follicles: Their antigenic profile and their identification as multinucleated giant cells.
Follicular dendritic cells are classified as cells of the accessory lymphoid system; they are also known as dendritic reticulum cells.
Antibody to CD21 demonstrated organized clusters of dendritic reticulum cells that corresponded to areas that were unequivocally follicular and accentuated the follicular growth pattern in areas that appeared vaguely nodular on hematoxylin-eosin stain (Figure, C).
A stain for dendritic reticulum cells demonstrated a typical pattern within germinal centers.