Antigen vaccines Tumor cell vaccine Dendritic cell vaccines
DNA vaccine Vector-based vaccines
A dendritic cell vaccine
increases the breadth and diversity of melanoma neoantigen-specific T cells," Science, vol.
ImmunoCellular's pipeline also includes ICT-121, a dendritic cell vaccine
targeting CD 133, and ICT-140, a dendritic cell vaccine
targeting ovarian cancer antigens and cancer stem cells.
According to the company, ICT-121 is a dendritic cell vaccine
. CD133 is highly expressed on cancer stem cells on most solid tumours, including brain, colon, non-small cell lung, melanoma, pancreatic and breast cancers.
The company said that ICT-140 is a dendritic cell vaccine
targeting seven antigens that are over-expressed in ovarian cancer, as well as cancer stem cells.
Rudnick et al., "Phase I trial of a multi-epitope-pulsed dendritic cell vaccine
for patients with newly diagnosed glioblastoma," Cancer Immunology, Immunotherapy, vol.
Bhardwaj, "CD8+ T cell priming by dendritic cell vaccines
requires antigen transfer to endogenous antigen presenting cells," PLoS ONE, vol.
These take several forms including peptide vaccines and dendritic cell vaccines
that are administered along with another agent to boost the immune response to the vaccine.
In order to make dendritic cell vaccines
some of the patient's dendritic cells are extracted and immune cell stimulants are used to reproduce large amounts of dendritic cells in the lab.