dendritic cell vaccine


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dendritic cell vaccine

An anticancer vaccine made by extracting dendritic (antigen-presenting) cells from a patient with cancer, stimulating those cells to reproduce themselves, and then exposing them to antigens taken from the patient's cancer. The antigenically exposed dendritic cells are then injected back into the patient.
See also: vaccine
References in periodicals archive ?
Antigen vaccines Tumor cell vaccine Dendritic cell vaccines DNA vaccine Vector-based vaccines
A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells," Science, vol.
ImmunoCellular's pipeline also includes ICT-121, a dendritic cell vaccine targeting CD 133, and ICT-140, a dendritic cell vaccine targeting ovarian cancer antigens and cancer stem cells.
According to the company, ICT-121 is a dendritic cell vaccine. CD133 is highly expressed on cancer stem cells on most solid tumours, including brain, colon, non-small cell lung, melanoma, pancreatic and breast cancers.
The company said that ICT-140 is a dendritic cell vaccine targeting seven antigens that are over-expressed in ovarian cancer, as well as cancer stem cells.
Rudnick et al., "Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma," Cancer Immunology, Immunotherapy, vol.
Bhardwaj, "CD8+ T cell priming by dendritic cell vaccines requires antigen transfer to endogenous antigen presenting cells," PLoS ONE, vol.
These take several forms including peptide vaccines and dendritic cell vaccines that are administered along with another agent to boost the immune response to the vaccine.
In order to make dendritic cell vaccines some of the patient's dendritic cells are extracted and immune cell stimulants are used to reproduce large amounts of dendritic cells in the lab.