demyelination


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Related to demyelination: vasculitis, Demyelinating diseases

demyelination

 [de-mi´ĕ-lin-a´shun]
destruction, removal, or loss of the myelin sheath of a nerve or nerves. Called also demyelinization and myelinolysis.

de·my·e·li·na·tion

, demyelinization (dē-mī'e-lin-ā'shŭn, dē-mī'ĕ-lin-i-za'shŭn),
Loss of myelin with preservation of the axons or fiber tracts. Central demyelination occurs within the central nervous system (for example, the demyelination seen with multiple sclerosis); peripheral demyelination affects the peripheral nervous system (for example, the demyelination seen with Guillain-Barré syndrome).

demyelination

Demyelinization Neurology A condition in which nerve trunks are not myelinated ab initio–eg, leukodystrophy or which suffer loss after myelinization has been completed–eg, myelinoclasia. See Leukodystrophy.

de·my·e·li·na·tion

, demyelinization (dē-mī'e-lin-ā'shŭn, -ī-zā'shŭn)
Loss of myelin with preservation of the axons or fiber tracts. Central demyelination occurs within the central nervous system (e.g., the demyelination seen with multiple sclerosis); peripheral demyelination affects the peripheral nervous system (e.g., the demyelination seen with Guillain-Barré syndrome).

demyelination

Loss of the insulating fatty sheath (myelin) of nerve fibres. This usually occurs in a patchy manner. Local areas of demyelination, in the form of ‘plaques’ which extend across large numbers of nerve fibre bundles, is the hallmark of MULTIPLE SCLEROSIS. Also known as demyelinization.

Demyelination

Disruption or destruction of the myelin sheath, leaving a bare nerve. Results in a slowing or stopping of impulses traveling along that nerve.

de·my·e·li·na·tion

, demyelinization (dē-mī'e-lin-ā'shŭn, -ī-zā'shŭn, dē-mīĕ-li-nāshŭn, -lin-ī-zāshŭn)
Loss of myelin with preservation of the axons or fiber tracts.
References in periodicals archive ?
However, post-infectious demyelination was considered because of the patient's smallpox vaccination history.
Fast potassium channels, present in the axon membrane under the myelin, are normally covered by myelin and uncovered by demyelination. Slow potassium channels are activated during sustained depolarization and high-frequency discharge and modulate repetitive firing patterns.
Histological analysis showed no demyelination in both the control groups and experimental groups [Figure 1].
Differences in RGC numbers, RGC axon staining, inflammation, and demyelination were compared using one-way ANOVA followed by Student-Newman-Keuls test using GraphPad Prism 5.0.
1 Another common finding is the tigroid pattern of demyelination which is also present in the index case (Figure-2).
We then detail the current imaging techniques utilized for both the detection of cortical demyelination and quantitation of both diffuse gray matter damage and gray matter atrophy.
Several previous studies demonstrated that the Hippocampal formation, among the various brain regions involved during the course of MS, is extensively sensitive to the detrimental effects of neuro-degeneration since hippocampal demyelination has been detected in approximately 53 % to 79 % of post-mortem brains in MS patients (Mancini et al., 2017).
But electrophysiological tests were abnormal and suggested an asymmetrical, sensory-motor axonal polyneuropathy, with secondary demyelination. His skin smear was negative for acid fast bacilli (AFB).
Hypernatremia is a potentially lethal condition, and can cause encephalopathy, rhabdomyolysis, and osmotic demyelination syndrome.
BioTime is a clinical-stage biotechnology company developing new cellular therapies for degenerative retinal diseases, neurological conditions associated with demyelination, and aiding the body in detecting and combating cancer.