Increased risk for demyelinating diseases
in patients with inflammatory bowel disease.
None of the patients with monophasic or monofocal demyelinating disease
of the brain were anti-AQP4 antibody positive.
White, "Human demyelinating disease
and the polyomavirus JCV"' Multiple Sclerosis, vol.
We conclude that the possible etiologies of demyelination include viral and/or immune-mediated factors similar to those seen in other demyelinating diseases
, such as multiple sclerosis and Guillain-Barre syndrome.
Thus, the presence or absence of OBs is one of the most helpful parameters in differentiating NMOSD from MS; MOG is a target of autoantibodies in animal models of inflammatory demyelinating diseases
of the CNS, such as MS.[sup] The role of MOG-Abs in diseases pathogenesis is unclear.[sup] Kim et al .
[2.] Antel JP, Arnason BGW: Demyelinating diseases
. Pages 2038-2045 in: Harrison's Principles of Internal Medicine, 12th ed, Wilson JD, Braunwald E, Isselbacher KJ, Petersdoff RG, Martin JB, Fauci AS, Root RK (editors).
Two groups of colleagues from the University of Cflifornia, San Diego and the Mayo Clinic have confirmed it with mice afflicted with a chronic viral demyelinating disease
. It was good to have it done in another model which has different requirements for the disease.
Based on those findings, demyelinating disease
and lymphoma were considered.
The patients who were provisionally diagnosed with demyelinating disease
, MS, optic neuritis or paraplegia during the field visits by the field teams were invited to the hospital to be examined by a neurologist blinded to the study.
TNF blockade both prevents and abrogates demyelinating disease
in vitro and in animal studies.
For years, some have claimed that hepatitis B vaccine causes demyelinating disease
and that measles, mumps, and rubella vaccine causes autism.
While a biopsy is rarely necessary for diagnosis in typical relapsing remitting MS, fulminant demyelinating disease
may present as a solitary, rapidly expanding mass lesion with radiographic enhancement and features suggestive of a neoplasm and biopsy is often necessary for definitive diagnosis.[5,13,16] The pathologist must he vigilant for the possibility of demyelination and avoid an incorrect diagnosis of brain tumor. An incorrect diagnosis of brain tumor may lead to inappropriate treatment with radiotherapy which may lead to serious long-term consequences particularly in younger patients.