demethylation


Also found in: Encyclopedia, Wikipedia.

de·meth·yl·a·tion

(dē-meth'i-lā'shŭn),
The enzymatic removal of methyl groups.
Farlex Partner Medical Dictionary © Farlex 2012
Mentioned in ?
References in periodicals archive ?
The absence of MDIPU and presence of DDIPU suggests either rapid demethylation of MDIPU to DDIPU in the soil or a greater retention of MDIPU by the soil.
LABORATORY SIMULATION STUDIES OF LEACHING OF THE PRIORITY PESTICIDES AND THEIR TRANSFORMATION PRODUCTS IN SOILS
To ensure the likelihood of a positive ROI, farmers should focus on applications at VT and use fungicides that include a mix of demethylation inhibitor and quinone outside inhibitor active ingredients.
Meta-analysis of yield response of foliar fungicide-treated hybrid corn in the United States and Ontario, Canada
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.
Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension
The latest study describes the demethylation process of Hg in marine fish (black seabream) after Se treatment.
REVISION OF RECIPROCAL ACTION OF MERCURY AND SELENIUM
The findings revealed that treatment with 10 [micro]M 5-Aza-CdR for 4 days induced partial demethylation of RASSF1A gene in PANC-1 cell line.
An Effective Concentration of 5-Aza-CdR to Induce Cell Death and Apoptosis in Human Pancreatic Cancer Cell Line through Reactivating RASSF1A and Up-Regulation of Bax Genes
Demethylation reporter HCT116 cells were generated and cultured as described previously [31].
Differential Regulation of Methylation-Regulating Enzymes by Senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs
These cells express the pluripotency-associated markers OCT3/4, LIN28A, and NANOG histologically and begin a process of global DNA demethylation necessary for the later establishment of sex-specific gametic imprinting [21-23].
Pediatric Germ Cell Tumors: A Developmental Perspective
rapa populations, the 5-azaC demethylation treatment altered plant size, and this change in size was heritable, but they did not examine life history changes or environmental interactions.
Experimental Treatment with a Hypomethylating Agent Alters Life History Traits and Fitness in Brassica rapa
Another similar study performed on DNA demethylation with 5-azaC showed increased miR-203 expression [33].
The Effects of MicroRNAs on Key Signalling Pathways and Epigenetic Modification in Fibroblast-Like Synoviocytes of Rheumatoid Arthritis
[33] demonstrated that the antipsychotic drugs clozapine and sulpiride increased the cortical and striatal demethylation of hypermethylated RELN and GAD1 promoters in the prefrontal cortex of mice after 7d of methionine treatment.
Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress Rats
An Epigenetics Screening Library was purchased from Cayman Chemical (Ann Arbor, MI) and consists of 148 small-molecule compounds that are involved in different epigenetic modifications such as DNA/histone methylation and demethylation as well as histone acetylation and deacetylation.
Development of a Cell-Based High-Throughput Screening Assay to Identify Porcine Host Defense Peptide-Inducing Compounds
In a growing human hair, Hcykeratin levels increase along the hair shaft as a result of copper and iron-dependent demethylation of methionine residues of keratin [18].
Mutations in Homocysteine Metabolism Genes Increase Keratin N-Homocysteinylation and Damage in Mice

Medical browser ?
Full browser ?