delta-6 desaturase enzyme

delta-6 desaturase enzyme (delˈ·t-siksˑ dē·saˑ·chu·ras enˑ·zīm),

n the rate-limiting step for converting linolenic acid or linoleic acid into longer essential fatty acid metabolites, (eicosapentaenoic acid and gamma linolenic acid).
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Delta-6-desaturase enzyme.
References in periodicals archive ?
Delta-5 and delta-6 desaturase enzyme activity (responsible for several conversions of LA and ALA down the synthesis cascade of eicosanoids) and are blocked by nutritional deficiencies of zinc, magnesium, selenium, B complex, and vitamin C as well as linoleic acid, saturated fat, trans fats, alcohol, monounsaturated fats (such as olive, canola, and peanut oil), inflammation, hyperglycemia, hypothyroidism, hypercholesterolem ia, protein deficiency, insulin resistance, oxidative stress, aging, genetics, and caffeine.
The delta-6 desaturase enzyme is not plentiful in humans and is significantly inhibited by age, lifestyle factors and dietary consequences.
The researchers mainly focused on polymorphisms in the fatty acid desaturase (FADS) gene cluster that encodes the delta-5 and delta-6 desaturase enzymes involved in the synthesis of long-chain fatty acids of the series omega-3 and omega-6.