dense granule

(redirected from delta granules)

dense granule

Cardiology
A specialised spherical storage and secretory vesicle in platelets which contains ADP, ATP, ionised calcium, pyrophosphate and serotonin. Reduced-platelet dense-granule secretion is associated with marked protection against arterial thrombosis, inflammation, and neointimal hyperplasia after vascular injury in a mouse model.

Pathology
Dense-core granules, see there.
References in periodicals archive ?
Normally, platelets contain two types of granules as alpha and delta granules.
In delta granule disorders, the first wave in platalet aggregometer is normal, but there is second wave defect in aggregation with ADP, collagen, epinephrine and/or arachidonic acid in relation with deficiency of delta granules.
On electrone microscopic examination, absence of delta granules in the platelets is typically observed in HPS and used in differentiation of HPS from other secretion defects together with clinical findings.