dense granule

(redirected from delta granules)

dense granule

Cardiology
A specialised spherical storage and secretory vesicle in platelets which contains ADP, ATP, ionised calcium, pyrophosphate and serotonin. Reduced-platelet dense-granule secretion is associated with marked protection against arterial thrombosis, inflammation, and neointimal hyperplasia after vascular injury in a mouse model.

Pathology
Dense-core granules, see there.
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References in periodicals archive ?
It is characterized by thrombocytopenia and deficient platelet calcium storage in delta granules. It presents overlapping symptoms with Stormorken syndrome.
Normally, platelets contain two types of granules as alpha and delta granules. Since factor V, vWF and fibrinogen are also included in alpha granules, some aggregation defect is also observed in specific deficiencies of these.
On electrone microscopic examination, absence of delta granules in the platelets is typically observed in HPS and used in differentiation of HPS from other secretion defects together with clinical findings.