deletion


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Related to deletion: deletion syndrome, Deletion mutation

deletion

 [de-le´shun]
in genetics, loss of genetic material from a chromosome.
 Examples of large-scale chromosomal deletions: A, terminal; B, interstitial. From Dorland's, 2000.

de·le·tion

(dĕ-lē'shŭn),
In genetics, any spontaneous elimination of part of the normal genetic complement, whether cytogenetically visible (chromosomal deletion) or found by molecular techniques.
[L. deletio, destruction]

deletion

(dĭ-lē′shən)
n.
1. The act of deleting; removal by striking out.
2. Material, such as a word or passage, that has been removed from a body of written or printed matter.
3. Genetics The loss, as through mutation, of one or more nucleotides from a chromosome.

de·le·tion

(dĕ-lē'shŭn)
genetics Any spontaneous elimination of part of the normal genetic complement, whether cytogenetically visible (chromosomal deletion) or inferred from phenotypic evidence (point deletion).
[L. deletio, destruction]

deletion

In genetics, the removal of a segment of DNA with joining up of the cut ends. as in the loss of a segment of a chromosome. Deletion of a single BASE PAIR is one of the kinds of point mutation. Deletion of a base pair triplet (codon) will result in a protein with a missing amino acid.

Deletion

The absence of genetic material that is normally found in a chromosome. Often, the genetic material is missing due to an error in replication of an egg or sperm cell.
References in periodicals archive ?
Of course, when malaria parasite density is low, malaria rapid diagnostic test (RDT) will not detect malaria even when there is no gene deletion in Plasmodium falciparum.'
FISH studies showed that 22 (7 males and 15 females) out of 39 patients had the 22q11.2 deletion (Fig.
GSTM1 deletion resulted in the absence of 219bp amplified product while absence of 459bp fragment meant homozygous deletion of GSTT1 gene.
In multiplex PCR group, one male fetus was identified as a patient with gene exonic deletion. In MLPA group, one female fetus was confirmed to be a carrier of gene exonic deletion and duplication each and carried the same maternal chromatids with probands.
Marangi et al., "A case of Beckwith-Wiedemann syndrome caused by a cryptic 11p15 deletion encompassing the centromeric imprinted domain of the BWS locus," Journal of Medical Genetics, vol.
Monogenic diabetes MODY 2 was suspected (mutations in GCK explains most cases of monogenic causes of diabetes in Spain) and MLPA was performed in the patient and her parents, showing an heterozygous GCK gene deletion and wild type results, respectively.
Deletion carriers had examples of brain overgrowth, such as an extension of the cerebellum, the bottom back part of the brain, toward the spinal cord.
A single a-gene deletion co-inheritance effects on [beta][degrees]-thal are very slight, while a milder disease have been seen in [[beta].sup.+] thai individuals with two [alpha]-gene deletions (2,14).
With the revised protocol, the positive predictive values increased to 44.2% for 22q11.2 deletion syndrome and 31.7% for the other four disorders combined.
Take deletion as an example, which is the most common mutation in structural variation [9].