deleterious

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deleterious

 [del″ĕ-tēr´e-us]
injurious; harmful.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

del·e·te·ri·ous

(del'ĕ-tēr'ē-ŭs),
Injurious; noxious; harmful.
[G. dēlētērios, fr. dēleomai, to injure]
Farlex Partner Medical Dictionary © Farlex 2012

del·e·te·ri·ous

(del'ĕ-tēr'ē-ŭs)
Injurious; noxious; harmful.
[G. dēlētērios, fr. dēleomai, to injure]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
The LRT method utilizes the log likelihood ratio of the conserved relative to neutral model to measure the deleteriousness of an nsSNP, with the null model that each codon is evolving neutrally with no difference in the rate of nonsynonymous to synonymous substitution and the alternative model that the codon has evolved under negative selection with a free parameter for the nonsynonymous to synonymous ratio [19].
PolyPhen adds the SwissProt feature table terms to the final prediction rules, and MutationTaster and SNAP also utilize the SwissProt annotations as features to predict the deleteriousness of the query nsSNPs.
During the training procedure, machine learning approaches are adopted to construct a classification and give a prediction score measuring the deleteriousness of an nsSNP.
The substitution of aspartic acid by asparagine is predicted to be tolerated, but SIFT, PolyPhen2, LRT, Mutation Taster, PROVEAN, and CADD point to the deleteriousness of this mutation.
Jian et al., "Comparison and integration of deleteriousness prediction methods for nonsynonymous SNVs in whole exome sequencing studies," Human Molecular Genetics, vol.