deleterious gene

deleterious gene

an ALLELE of a gene whose effects on the PHENOTYPE are likely to result in a reduced FITNESS. Such genes are often recessive, so that they can be transmitted through families without being detected unless two occur together in the same individual.
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In this case, the researchers mended a deleterious gene variant that causes enlarged hearts and often results in sudden death early in life.
Since mitochondria] conditions have extensive clinical overlap and there are currently more than 100 known genes linked to mitochondrial energy production disorders, the diagnosis and identification of the deleterious gene would have been nearly impossible before the introduction of NGS.
For example, if she has a deleterious gene that is an autosomal dominant, her children have a 50 percent chance of developing the disorder, and Z has a 100 percent chance of developing that disorder herself.
By chance a rare deleterious gene is found in the group that initiated a new settlement.
With October marking the 25th anniversary of National Breast Cancer Awareness Month, it should be noted that females with a deleterious gene mutation are being diagnosed with breast cancer almost eight years earlier than relatives of the previous generation who also had the disease, according to research from the University of Texas MD Anderson Cancer Center, Houston.
Other tests will warn prospective parents of possible deleterious gene combinations in their future progeny.
Gruber added that once DNA diagnostics using Hyseq's technology become available, the next stage would be the development of therapeutics to treat or replace deleterious gene mutations.
Joh offers scenarios in which clandestine genetic testing could be used by a politician to reveal a rival's disease risks, determine an athlete's chances of heart problems before offering him a contract, publicize a personal enemy's predispositions to alcoholism or obesity, check a romantic partner for possibly deleterious genes that could be passed on to progeny, or satisfy a creepy fan's interest in a celebrity's genetic makeup.
Financially secure, these businessmen were able to support larger families, thereby potentially transmitting the deleterious genes to many progeny.
The aim, say the scientists, is not to identify so-called bloodlines that carry deleterious genes, but to better quantify risks for individual horses so that these horses can be managed differently, through training, feeding or other environmental modifications.
Hybrid breeding programs must therefore be designed for selecting complementary Rf gene combinations, allowing accumulation of beneficial genes and the elimination of deleterious genes (Lucken, 1987).
In a 1997 survey published in the Journal of Contemporary Health Law and Policy, researchers found that 13 percent of English geneticists, 50 percent of Eastern and Southern European geneticists, and 100 percent of Chinese and Indian geneticists agreed with the eugenic suggestion that "an important goal of genetic counseling is to reduce the number of deleterious genes in the population.