In his model, only functional portions of the genome can be damaged by deleterious
mutations; mutations in nonfunctional portions are neutral since functionless parts can be neither damaged nor improved.
PARP inhibitors represent a novel targeted therapy for ovarian cancer, particularly those with deleterious
germline or somatic BRCA mutations.
1%) were predicted to be deleterious
, but the others were neutral (Figure 1).
Exposure of preexisting, deleterious
alleles is, incidentally, a major cause of cancer, he adds.
This mutation is a known deleterious
mutation in the CFTR gene.
impacts have increased public awareness and demand for intervention to reduce or eliminate bloom impacts on coastal resources, local economies, and threats to public health.
The practice often has a deleterious
effect in developing countries, overpowering local producers or discouraging expanded agricultural development.
The extracts may also be administered to non-diabetics without deleterious
How is it possible to distinguish between sequence variations that are deleterious
for the stability or for the function of the protein, leading to a disorder, and neutral variations that do not modify the phenotype?
As our knowledge advances, we have a progressively lower tolerance for deleterious
materials in our food and water, particularly with respect to their impact on children.
According to these results, autocausticizing should have no deleterious
effects on the properties of pulps derived from maple, spruce, and birch.