Traditional open reduction and internal fixation with plates carry high rates of complications like infection, delayed union
and non-union as a consequence of periosteal stripping.
The most common cause of nail breakage is metal fatigue secondary to delayed union
or nonunion [3,8].
In the search for "signals" of MSC regenerating ability, we evaluated prospectively a cohort of patients affected by long bone delayed union
or nonunion enrolled in a "Seventh Framework Program" (FP7) European project and treated with a regenerative therapy with expanded autologous MSC plus a synthetic bone substitute.
Two percent (2.2%) complications were seen in cases of infection, delayed union
, limited mouth opening and miniplate removal.
Two patients (8%) developed delayed union
from group A and were treated by dynamization.
The published series of these injuries recorded varying incidences of delayed union
or non-union, malunion, infection, joint contractures and post traumatic arthritis.
In the USA alone, delayed union
occurs in an estimated 600.000 patients with fractures each year, and approximately 100.000 of them progress to nonunions.
No statistically significant difference was found when comparing the rates of infection, rotation, shortening, delayed union
Two patient groups were not significantly different in relation to postoperative normal occlusion (p=0.45), malocclusion (p=0.45), mal-union (p=0.45), delayed union
(p=0.07), non union, infection (p=0.28) and sensory disturbances (p=0.07).