delayed graft function

Also found in: Acronyms.

delayed graft function

A form of acute renal failure resulting in post-transplantation oliguria, increased allograft immunogenicity and risk of acute rejection episodes, and decreased long-term survival, which are linked to the donor and prerenal, renal or postrenal transplant factors related to the recipient.

Pathogenesis
Delayed graft function is linked to ischaemia and reinstitution of blood flow in ischaemically damaged kidneys after hypothermic preservation.

References in periodicals archive ?

All the patients who had delayed graft function required hemodialysis post-surgery for optimization of kidney function.

Can zero-hour cortical biopsy predict early graft outcomes after living donor renal transplantation?

Uni- and multi-variate analyses of donor variables associated with delayed graft function in development cohort

Predictive Score Model for Delayed Graft Function Based on Easily Available Variables before Kidney Donation after Cardiac Death

Review Delayed graft function in kidney transplantation.

Medicion del NGAL urinario en el donante para detectar funcion retardada del injerto renal en el receptor

Delayed graft function and the risk of death with graft function in living donor kidney transplant recipients.

Kidney transplant outcomes following the introduction of hand-assisted laparoscopic living donor nephrectomy: a comparison of recipient groups

Studies focused on NGAL revealed high serum and urinary levels in patients with delayed graft function, defined as the need for dialysis in the first week after transplantation, concluding that urinary and serum NGAL measurement could be a promising biomarker in the early post-transplantation period [30-31].

Acute tacrolimus nephrotoxicity in kidney transplanted patients--from kidney biopsy to urinary markers of acute kidney injury: a case report

The reason why ischemia did not result in acute tubular necrosis, delayed graft function in this patient is that this kidney had started diuresing postoperatively and later due to vascular kink ceased diuresing.

Results of Separate Anastomoses of Multiple Renal Arteries with Recipient External Iliac Artery in Renal Transplant Surgery

As BMI increased, patients had significantly higher rates of delayed graft function.

Transplant lists may favor nonobese patients

Delayed graft function (DGF) was defined as a requirement for dialysis during the first 2 weeks after transplantation.

Changes in plasma cystatin C after renal transplantation and acute rejection in adults

PA401 has also been granted Orphan Drug designation in the US and EU for the "prevention of delayed graft function after solid organ transplantation".

ProtAffin AG starts Phase 1 study for lead product PA401 in inflammatory lung disease

Unfortunately, expanded criteria kidneys often caused a delayed graft function, which typically resulted in a more complicated postoperative course.

Responses to a survey on the perceived barriers to effective discharge planning in renal transplant recipients

Also, the Phase II study also shows that IdeS treatment resulted in negative cross match test in all patients, none of the transplanted patients experienced delayed graft function and all 10 transplantations resulted in very good creatinine levels.

Hansa Medical reports top line results from ongoing Phase II study with IdeS in Sweden