Association between
delayed graft function and allograft and patient survival: a systematic review and meta-analysis.
Predictive score model for
delayed graft function based on easily available variables before kidney donation after cardiac death.
HLA: human leukocyte antigen; DGF:
delayed graft function; POD: post-operative days; PCR: protein/creatinine ratio.
LRD, LURD, p-value (n = 28) (n = 42) Primary non-function 0 2 (4.7) 0.301
Delayed graft function 0 2 (4.7) 0.301 Surgical 5 (17.8) 18 (42.8) 0.005 complication RAS 1 (3.5) 4 (9.5) 0.440 Wound infection 0 3 (7.1) 0.540 Obstruction/leaks 0 5 (11.9) 0.095 Recurrent UTI 4 (14.2) 5 (11.9) 0.356 Deep vein 0 1 (2.3) 0.468 thrombosis Viral infection 16 (57.1) 19 (45.2) 0.747 CMV 4 (14.2) 7 (16.6) 0.111 EBV 1 (3.5) 1 (2.3) 0.723 BKV 4 (14.2) 5 (11.9) 0.542 Warts virus 3 (10.7) 3 (7.1) 0.523 Hepatitis C virus 0 2 (4.7) 0.124 Herpes virus 4 (14.2) 1 (2.3) 0.054 Fungal infection 0 3 (7.1) 0.202 Early 0 5 (11.9) 0.230 nephrectomy Malignancy 1 (3.5) 2 (4.7) 0.896 Hypertension 15 (53.3) 31 (73.8) 0.147 Acute rejection 5 (17.8) 9 (21.4) 0.747 Datapresentedas n (%).
Delayed graft function occurs in 10-31% cases in patients with DKT [16, 18-22, 24, 32, 34].
The association of urinary tract infections with
delayed graft function was shown earlier by some authors [50].
In addition, transplanted kidney undergoes various stressors including warm ischemia, cold ischemia, and
delayed graft function and, later on, rejection and exposure to calcineurin inhibitors.
Delayed graft function rate (%)###6.3%###6.8%###70 years) does not affect graft survival in the medium term.
van Es, "Calcium levels as a risk factor for
delayed graft function," Transplantation, vol.
This event can lead to immediate and long-term graft dysfunction, such as allograft rejection,
delayed graft function (DGF), and even primary nonfunction (PNF) [1].
Infections, like urinary and cytomegalovirus infections, and
delayed graft function were the most frequent complications.