* Nevirapine is similar to delavirdine
, causing a decrease of about 50% in methadone area-under-the-curve concentrations.
The relative retention factors (k' values) for several other drugs that are commonly used as either antiviral drugs (DMP 266, delavirdine
, and nucleosides) or drugs that are used to prevent or treat opportunistic infections (azole antifungals, macrolides, atovaquone, rifabutin, rifampin, trimethoprim, and sulfamethoxazole) are listed in Table 5.
mesylate (DLV, Rescriptor), Pharmacia & Upjohn
For example, a study of the drug delavirdine
, in which 19 percent of the participants were women, showed a longer retention time in women s bodies than in men s (Women Alive, 1997).
Some of those ongoing trials test drugs, such as AZT (zidovudine), didanosine (ddI), and delavirdine
, that target reverse transcriptase, the enzyme HIV uses to integrate its genetic material into host cells.
US FDA PREGNANCY CATEGORIES FOR CURRENTLY APPROVED ANTIRETROVIRALS Drug FDA category Abacavir C Didanosine B Emtricitabine B Lamivudine C Stavudine C Tenofovir B Zalcitabine C Zidovudine C Delavirdine
C Efavi renz D Nevirapine C Amprenavir C Atazanavir B Darunavir B Fosamprenavir C Indinavir C Lopinavir + C ritonavir Nelfinavir B Ritonavir B Saquinavir B Tipranavir C Enfuvirtide B FDA categories defined as: A: Adequate and well-controlled studies of pregnant women fail to demonstrate a risk to the fetus during the first trimester of pregnancy (and no evidence exists of risk during later trimesters).
NRTI: nucleosidic inhibitor of reverse transcriptase; NNRTI: non- nucleosidic inhibitor of reverse transcriptase; PI: protease inhibitor; 3TC: lamivudine; ABC: Abacavir; ZDV: Zidovudine; d4T: stavudine; TDF: Tenofovir; ddI: Didanosine; DLV: Delavirdine
; EFV: Efavirenz; NVP: Nevirapine; NFV: Nelfinavir; SQV: Saquinavir; RTV: Ritonavir; ATZ: Atazanavir.
folate vit B12 * Dysmegakaryopoiesis (direct HIV infection, drugs, cytokines from other infections or malignancies, etc.) * Direct infections of the bone marrow * Malignancies infiltrating the bone marrow * Amegakaryopoiesis, hereditary causes (May-Hegglin, etc.) * Drugs: delavirdine
and nelfinavir (see Table I) Peripheral consumption * Idiopathic thrombocytopenic purpura * Diffuse intravascular coagulopathy * Thrombotic thrombocytopenic purpura Peripheral sequestration/hypersplenism * Infections * Haemophagocytosis * Cirrhosis
1995,288:201-207 (37) TABLE 3 Drugs that induce or inhibit CYP3A4 Inducers Barbiturates Glucocorticoids Carbamazepine Modafinil Dexamethasone Nevirapine Efavirenz Phenobarbital Weak/moderate Amiodarone Diltiazem inhibitors Anastrozole Fluconazole Chloramphenicol Fluoxetine Cimetidine Fluvoxamine Ciprofloxacin Metronidazole Clotrimazole Mibefradil Danazol Miconazole Delavirdine
Strong inhibitors * Clarithromycin Indinavir Erythromycin Itraconazole Inducers Phenylbutazone Rifabutin Phenytoin Rifampin Pioglitazone St.
* The FDA approves the NNRTI delavirdine
Some patients may be sensitive to non-nucleoside reverse transcriptase inhibitors such as nevirapine, delavirdine
, and efavirenz.
This is a very active antiretroviral of the NNRTI class (non-nucleoside reverse transcriptase inhibitor -- the same class as efavirenz, nevirapine, and delavirdine
, the three NNRTI drugs currently approved in the U.S.).