dehydrogenase


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dehydrogenase

 [de-hi´dro-jen-ās″]
an enzyme that mobilizes the hydrogen of a substrate so that it can pass to a hydrogen acceptor.
glucose-6-phosphate dehydrogenase an enzyme necessary for the oxidation of glucose-6-phosphate, an intermediate in carbohydrate metabolism. Hereditary deficiency of this enzyme in the erythrocytes is associated with a tendency toward hemolysis upon ingestion of certain antimalarial agents and sulfonamide drugs and fava beans (see favism.
lactate dehydrogenase (LDH) an enzyme that catalyzes the interconversion of lactate and pyruvate. It is widespread in tissues and is particularly abundant in kidney, skeletal muscle, liver, and myocardium. It appears in elevated concentrations when these tissues are injured.

de·hy·dro·gen·ase

(dē-hī'drō-jen-ās),
Class name for those enzymes that oxidize substrates by catalyzing removal of hydrogen from metabolites (hydrogen donors) and transferring it to other substances (hydrogen acceptors), which are thus reduced; most of the oxidative enzymes (oxidoreductases, EC class 1) perform their oxidations in this manner.

dehydrogenase

(dē′hī-drŏj′ə-nās′, -nāz′, dē-hī′drə-jə-)
n.
An enzyme that catalyzes the removal of hydrogen from a substrate and the transfer of the hydrogen to an acceptor in an oxidation-reduction reaction.

de·hy·dro·gen·ase

(dēhī-drojĕ-nās)
Class name for those enzymes that oxidize substrates by catalyzing removal of hydrogen from metabolites (hydrogen donors) and transferring it to other substances (hydrogen acceptors).

dehydrogenase

an enzyme, such as any of the respiratory enzymes, that catalyses a reaction in which hydrogen is removed from a molecule (often to be taken up by the ELECTRON TRANSPORT SYSTEM). For example, in the KREBS CYCLE the conversion of succinic acid (succinate) to fumaric acid (fumarate) is catalysed by succinate dehydrogenase, the hydrogen released being passed on to FAD.

de·hy·dro·gen·ase

(dēhī-drojĕ-nās)
Class name for those enzymes that oxidize substrates by catalyzing removal of hydrogen from metabolites (hydrogen donors) and transferring it to other substances (hydrogen acceptors).
References in periodicals archive ?
Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer.
Estimating the fluid Lactate Dehydrogenase levels in patients presenting with ascites helps in differentiating between malignant and non-malignant effusion.
Severe hemolysis and renal failure in glucose-6-phosphate dehydrogenase deficient patients with hepatitis E.
Severe neonatal hyperbilirubinemia: a potential complication of glucose-6-phosphate dehydrogenase deficiency.
Fiorelli, "Glucose-6-phosphate dehydrogenase deficiency," The Lancet, vol.
Pyruvate is decarboxylated by pyruvate dehydrogenase (PDH) to acetyl-CoA, which is then condensed with oxalacetate to citrate via the citrate synthase (CS).
McAlister-Henn, "NAD+-dependent isocitrate dehydrogenase. Cloning, nucleotide sequence, and disruption of the IDH2 gene from Saccharomyces cerevisiae," Journal of Biological Chemistry, vol.
This results in a less functional acetaldehyde dehydrogenase, an enzyme that's charged with the breakdown of acetaldehyde. The net result is that affected people may be better at metabolizing alcohol, but show far more acetaldehyde-based side effects while drinking.
The structure of the yeast NADH dehydrogenase (Ndil) reveals overlapping binding sites for water- and lipid-soluble substrates.
(1) The 3-beta hydrox-yseteroid dehydrogenase (3-BHSD) enzyme is one of the most proximal enzymes essential for steroidogenesis in both the adrenal cortex and gonads.
Of the many isoenzymatic systems, malate dehydrogenase (MDH), acid phosphatase (ACP), phosphoglucose isomerase (PGI), 6-phosphogluconate dehydrogenase (PGD) and isocitrate dehydrogenase (IDH) were reported to be most informative for characterization of maize inbreds (Mauria et al., 2000).
Dehydrogenase enzyme activity was similar in maize plots and slightly increased in clover BGR40 compared to control.