dehydrocholic acid

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dehydrocholic acid

[de-hi″dro-ko´lik]

a synthetic bile acid used to increase output of bile by the liver and the filling of the gallbladder. Preparations of this acid are used to aid the digestion of fats and increase absorption of fat-soluble vitamins. Drugs containing dehydrocholic acid are contraindicated in cases of biliary obstruction. Because of the bitter taste on the tongue after it is injected into a vein, it is used to provide an end point for the measurement of arm-tongue circulation time.

de·hy·dro·cho·lic ac·id

(dē-hī'drō-kol'ik as'id),

Agent with a stimulating effect on the secretion of bile by the liver (choleretic); improves absorption of essential food materials in states associated with deficient bile formation.

dehydrocholic acid

(dē-hī″drō-kŏl′ĭk)

A bile salt that stimulates production of bile from the liver.

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References in periodicals archive ?

Sarmiento, "Thermodynamic and elastic fluctuation analysis of langmuir mixed monolayers composed by dehydrocholic acid (HDHC) and didodecyldimethylammonium bromide (DDAB)," Colloids and Surfaces B: Biointerfaces, vol.

The effect of hydroxyl moieties and their oxosubstitution on bile acid association studied in floating monolayers

The concentration of free radicals (N) in the UV irradiated dehydrocholic acid (during 30 and 60 minutes) were about 169.10 x [10.sup.17] spin/g and 178.10 x [10.sup.17] spin/g, respectively (Table 1).

Relatively less changes of this parameter are observed for dehydrocholic acid. Depending on the applied temperature, the concentration of free radicals in investigated dehydrocholic acid is placed in the range of 0.50 x [10.sup.16] spin/g (at 170[degrees]C) to 2.80 x [10.sup.16] spin/g (at 180[degrees]C) (Table 2).

Effect of UV irradiation and temperature on free radical properties in dehydrocholic and ursodeoxycholic acids: an EPR study

This compound, dehydrocholic acid, represents a known hydrocholeretic drug that increases bile flow by increasing mainly the aqueous fraction, but not so much the synthesis of bile acids.

Choleretic activity and biliary elimination of lipids and bile acids induced by an artichoke leaf extract in rats