It is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase, and thus, this prevents the formation of toxic metabolites such as SA which have been shown to block the of delta 5-aminolevulinic acid dehydratase
in the heme biosynthesis.
Sassa, "Aminolevulinic acid dehydratase
assay," Enzyme, vol.
 Nonstandard abbreviations: AIP, acute intermittent porphyria; ALA, aminolevulinic acid (ALA); PBG, porphobilinogen; ALAD, ALA dehydratase
Earlier studies reported that Cd suppressed the activity of enzymes such as d-aminolevulinic acid dehydratase
and proto-chlorophyllide reductase required for the biosynthesis of pigments (Qian et al., 2009).
The inactivation of intracellular Fe-S cluster will damage the Fe-S dependent proteins, especially Fe-S dependent dehydratases
such as dihydroxy-acid dehydratase
In LP, the metal directly inhibits aminolevulinic acid dehydratase
Furthermore, in [Ogg1.sup.-/-] HCCs, significant overexpression of keratins 8 (KRT8) and 18 (KRT18), prohibitin 1 (PHB1), calreticulin (CALR), and histidine triad nucleotide-binding protein 1 (HINT1) transcriptional factors, vimentin (VIM), chitinase-like 3 (Chil3), serine dehydratase
(SDS), methionine adenosyltransferase 1A (MAT1A), and PGRMC1 was detected.
Relationship in the adolescent and adult US inactivated delta-aminolevulinic acid dehydratase
of whole blood and the blood lead level.
The predicted tertiary structures of the six pseudogenes (STM3828.1N, STM3191, STM4431, fucP, STM0326 and STM1553) showed considerable structural homology with bacterial 2-dehydro-3-deoxy-6-phosphogalactonate aldolase, aryl sulfate sulfotransferase, acetohydroxy-acid synthase, L-fucose transporter, glycerol dehydratase
activator and paired box proteins respectively (Fig.
Previous studies have reported association between blood lead levels (BLLs) with neurobehavioral impairments,  genotoxic effects,  impaired coagulation,  health illness,  hypertension,  decreased [??]-aminolevulinic acid dehydratase
& elevated [??]-aminolevulinic acid,  ocular changes,  respiratory, gastrointestinal & musculoskeletal morbidities,  epigenetic changes,  decreased bone mineral density,  oxidative stress,  dental problems,  altered gene polymorphisms, [14-16] increased risk of cardiovascular disease,  anemia & abdominal pain ; and decreased enzymatic antioxidants  among lead battery manufacturing workers.
Indeed, levels over 10 qg/dL have been demonstrated to impair aminolaevolunic acid dehydratase
(ALAD), which is an important enzyme required for heme synthesis.
[20.] Rendon-Ramirez A, Cerbon-Solorzano J, Maldonado-Vega M, Quintanar-Escorza MA, Calderon-Salinas JV (2007) Vitamin-E reduces the oxidative damage on delta-aminolevulinic dehydratase
induced by lead intoxication in rat erythrocytes.