degranulation


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de·gran·u·la·tion

(dē-gran'yū-lā'shŭn),
Disappearance or loss of cytoplasmic granules from a cell or activation of granulocytic cells (for example, neutrophils, mast cells, basophils, eosinophils).

degranulation

(dē-grăn′yə-lā′shən)
n.
The process of losing granules.

degranulation

[dēgran′yəlā′shən]
the release of granules from cells, such as mast cells and basophils.

degranulation

the loss of granules; usually refers to the secretory granules in certain cells, e.g. pituitary chromophobes, acidophils and basophils. In basophils and mast cells, it is associated with the release of active substances from the cells and is characteristic of type I immediate hypersensitivity.
References in periodicals archive ?
1) Toxicity, evidenced by increased cytoplasmic basophilia and degranulation, was also noted among heterophils and, with the presence of a left shift in this series, indicated an inflammatory leukogram.
They are advised to avoid foods, medications, and environmental triggers that can cause mast cell degranulation.
The edema component is generated by mast-cell degranulation and can be uncoupled using selective [H.
Schaafsma and his colleagues suggested that insulin enhances the degranulation of mast cells so increased release of mediators like histamine and prostaglandins are responsible for airway hyper-reactivity6.
This is a result of the offending agent binding directly to mast cells and inducing their degranulation with release of inflammatory mediators, particularly histamine, [3] leading to angio-oedema and urticaria.
8, in methanol),Silanized glass vials containing heparin(N) (porcine), 20 units, for collection of 1-ml whole blood,Siliconized vials for incubation of samples,Stimulant for NBT Assay (Bacterial extracts (nonviable), lyophilized),Nitroblue Tetrazolium (NBT) Reduction Kit,Basophil Degranulation assay kit
Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen- activated protein kinases.
IN VITRO EFFECT OF THE PROTEIN EXTRACT OF Sarcocystis aucheniae MACROCYSTS ON THE VIABILITY AND DEGRANULATION OF RABBIT (Oryctologus cuniculus) LEUKOCYTES
It is a chemoattractant that has been found to be elevated in volume during an asthmatic bronchospasm and may have a significant role in triggering the activation and degranulation of eosinophils [5, 6].
Salmeterol, formoterol, and arformoterol inhibit human mast cell activation and degranulation in vitro, prevent an increase in vascular permeability with inflammatory mediators, and generally diminish the attraction and accumulation of airway inflammatory cells.
Benzylisoquinolinium compounds, such as d-tubocurarine, metocurine, doxacurium, atracurium, and mivacurium, are more likely to cause direct mast cell degranulation than aminosteroid compounds such as pancuronium, vecuronium, rocuronium, and pipecuronium.
The type-1 hypersensitivity that causes progressive mast cell degranulation could be the trigger factor for acute appendicitis.