The inverse correlation was dose-dependent; 10-year HCC risk was lowest with 600 or more lipophilic statin cumulative defined daily doses
(cDDDs) compared with nonuse (8.4 versus 2.5 percent; RD, −5.9 percent; aHR, 0.41; 95 percent CI, 0.32 to 0.61).
An NHS Grampian spokesman added: "As an organisation we look at more standardised measures of opioid consumption, including the number of defined daily doses
of drugs being prescribed, rather than solely the number of patients who have been given them.
The report finds wide discrepancies in consumption rates between countries, ranging from approximately 4 defined daily doses
(DDD)/1000 inhabitants per day to more than 64 DDD.
The "WHO Report on Surveillance of Antibiotic Consumption" looked at antibiotic use in 65 countries and found the Netherlands used 9.78 defined daily doses
(DDD) per 1,000 people, while Britain used twice as much and Turkey almost twice as much again, at 38.18 DDD per 1,000 inhabitants.
This he said has been compounded by disturbingly high antibiotic consumption in the country from 800 million defined daily doses
(DDD) to 1.3 billion DDD between 2000 and 2015.
For example, anticholinergic use consistent with the highest dose category (more than 1,460 defined daily doses
) was associated with an adjusted odds ratio for dementia of 1.57 (95% confidence interval, 1.18-2.09) for probable and 1.31 (95% CI, 1.22-1.41) for definite anticholinergics.
For the last decade and a half, antibiotic consumption in the country has grown by 500 million defined daily doses
. This is a remarkable surge and catapults the country into the third spot among low and middle income countries with the highest consumption of antibiotics.
Antibiotic consumption in Pakistan between 2000 and 2015 increased 65 per cent from 800 million defined daily doses
(DDD) to 1.3 billion DDD, the report said.
High use of HCTZ was defined as filled prescriptions totaling greater than or equal to 50,000 mg of HCTZ, which corresponds to greater than or equal to 2,000 defined daily doses
(for example, approximately 6 years of cumulative use).
(23,24) To the best of our knowledge, this is the first study NSAID utilization was measured and compared as the total number of defined daily doses
. Naumann et al.
Discrepancies between prescribed and defined daily doses
: a matter of patients or drug classes?