Effects of Quercetin as Compared to Deferoxamine
on Small Intestinal Iron Levels in Iron Overloaded Rats.
reduces cavity size in the brain after intracerebral hemorrhage in aged rats," in Intracerebral Hemorrhage Research, vol.
Nishino, "Treatment with deferoxamine
increases neurons from neural stem/progenitor cells," Brain Research, vol.
Risk factors for HCV infection other than blood transfusion in [beta]-TM patients Characteristic HCV-infected HCV-not p patients (%) infected (%) value Surgery 44.7 55.3 0.062 Deferoxamine
38.4 61.6 0.58 intake Splenectomy 54.8 45.2 0.004 Family history of 37.5 62.5 0.76 [beta]-TM Gender Male 33.3 66.7 0.83 Female 34.6 65.4 Discussion
The results are presented in two separated categories for deferoxamine
injection and blood transfusion.
The team used two FDA-approved iron chelators, deferoxamine
and deferasirox, that can remove excess iron from the system by binding to the metal in a process called chelation.
The study is a follow-up to a 1-year, randomized, open-label, phase II trial that evaluated the safety and tolerability of deferasirox, given once daily as a dispersed solution in water, versus those of deferoxamine
, given as a subcutaneous infusion in adults and children.
In the 1-year trial, the initial doses of deferasirox and deferoxamine
were assigned according to patients' baseline liver iron concentration.
The analysis included data on 1,033 patients, including 330 who were in a crossover cohort of patients previously treated with deferoxamine
Exclusion criteria were chronic hepatitis virus B or C infection, treatment with deferoxamine
, or blood donation before hemochromatosis diagnosis.
mesylate Abbott Laboratories Desferal for
(acute and chronic iron) causes toxicity in two animal species, but human pregnancy experience is substantial, and no embryonic or fetal adverse effects attributable to the agent have been reported.