defensin


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defensin

A small (29 to 34 amino acid) cationic peptide produced in neutrophils and epithelial cells, which may be involved in nonspecific response to microbes.

Types
ß-defensin 1—expressed in alveolar epithelia of normal individuals, but not in patients with cystic fibrosis.
ß-defensin 2—first identified in the skin of patients with psoriasis who have a decreased susceptibility to skin infections.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

defensin

(dē-fĕn′sĭn) [term coined by Robert I. Lehrer, U.S. physician, b. 1938]
Destructive peptides (groups of amino acids) found in the granules of neutrophils and other phagocytic cells that kill bacteria and fungi by destroying their membranes. Defensins are active against bacteria, fungi, and enveloped viruses in vitro. They may contribute to host defenses against susceptible organisms.
Medical Dictionary, © 2009 Farlex and Partners
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References in periodicals archive ?
Human defensin 5 disulfide array mutants: disulfide bond deletion attenuates antibacterial activity against Staphylococcus aureus.
Results: The promoters of the defensin A4 and cecropin B1 genes produced robust expression of luciferase and GFP in the Ae.
The study showed that 89.5% of subjects with an infection diagnosis based on standard of care criteria were identified as positive for alpha defensin by the Synovasure Lateral Flow Test Kit.
Defensin, hepcidin and chemerin are some of the antimicrobial proteins.4 Hepcidin is a recently discovered hormone which is synthesized in the liver and is an antimicrobial protein displaying antibacterial and antifungal properties and maintains iron balance in the microorganism thus regulating its metabolism.
[5,6] Antimicrobial peptides present in breast milk include lactoferrin, alpha defensins beta defensin, lysozyme, lacto-peroxidase.
Bu reseptorler vucuda giren mikroorganizmalari taniyarak dogal immun sistemi aktive etmekte, antimikrobiyal peptidler (cathelicidin ve defensin gibi) ve oksijen radikallerinin salinimina neden olmaktadir.
Regarding freshwater bivalves, the molecules that may be involved in this antibacterial response are still unidentified; however, breakthroughs in this field may start to appear, because a big defensin gene was recently identified in the freshwater mussel Hyriopsis cumingii (Wang et al.
The Rs-AFP1 and Rs-AFP2 (AMPs from Raphanus sativus seeds belong to the plant defensin family) were observed to act synergistically with caspofungin to inhibit the Candida albicans biofilm [45].
These AMPs include beta defensin 1 (BD1) and beta defensin 2 (BD2), which have potent antimicrobial effects on gram-positive and gramnegative organisms, including methicillin-resistant S.
HNP: Human neutrophil peptide ELISA: Enzyme-linked immunosorbent assay AdV: Adenovirus HPV: Human papillomavirus HBD: Human beta-defensins HD: Human defensin MMP: Matrix metalloproteinase W: Tryptophan F: Phenylalanine Y: Tyrosine CAR: Coxsackievirus and adenovirus receptor UTI: Upper respiratory tract infections TMB: Tetramethylbenzidine.
Weinberg, "Defensin gene variation and HIV/AIDS: a comprehensive perspective needed," Journal of Leukocyte Biology, vol.