deep sequencing


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deep sequencing

Examination of a nucleic acid genome with such precision that even very rare genetic mutations are identified.
See also: sequencing
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In terms of the cause of the hepatic cytolysis rebound in the 2 patients reported here, neither had taken a hepatotoxic drug during the rebound period, and results of deep sequencing for eukaryotic pathogens and autoimmune antibodies were negative.
The viruses detected by small RNA deep sequencing were characterized further by amplification of partial genome sequences using reverse transcription PCR (RT-PCR).
A comparative profile of the micro-RNA transcriptome in immature and mature porcine testes using Solexa deep sequencing. FEBS J 2012;279:964-75.
To study the impact of Adv infection on cellular small RNA expression in pneumonia children, deep sequencing of small RNAs was performed in our study.
Deep sequencing identifies novel and conserved microRNAs in peanuts (Arachis hypogaea L.).
Now, the deep sequencing technology is able to identify all the transcripts, even lacking detailed genetic information or with no reference genome [8].
Using a technique called deep sequencing, the team identified miR-155 as a potential part of this process.
Second, the flexibility of targeted gene panel design and the availability of deep sequencing depth on NGS allow to simultaneously sequence all known genes for certain genetic disease and to comprehensively analyze SNVs, small InDels, and copy number variations at a high accurate level.
Bacterial communities associated with host-adapted populations of pea aphids revealed by deep sequencing of 16S ribosomal DNA.
Deep sequencing the transcriptome reveals seasonal adaptive mechanisms in a hibernating mammal.
The concept behind Grail's proposed blood test--one that they call "The Early Detection ctDNA Hypothesis"--relies on deep sequencing of ctDNA.
Enter "deep sequencing," also known informally as "next-generation sequencing." Modern molecular and computation techniques have reduced the cost of sequencing the entire genome of any organism 100,000-fold since 2001, to the extent that it is now practical to simply sequence the entire DNA (or millions of markers) in a sample, subtract the bits that are known to be the grape genome and identify viral DNA amongst the "leftover" DNA.