We propose that these results provide a proof of concept for epigenetics-driven cancer development, and suggest that particular types of cancer, such as Wilms' tumor, might arise mainly as a result of dedifferentiation
disrupting epigenetic regulation (Fig.
Impairment of cell cycle control Replicative senescence Accumulated mutations Dedifferentiation
Lack of Contact inhibition Formation of blood vessel network Invasiveness Metastasis Table 2: Specific CSC markers and function [adapted from ].
In the present study, WDTC undergoing dedifferentiation
was defined as primary WDTC with dedifferentiated components at primary or metastatic sites.
Seidler, "Evidence for motor cortex dedifferentiation
in older adults," Neurobiology of Aging, vol.
Louis, MO, catalog number C-1768; 10 [micro]M for 24 h.) to reduce proliferating cells and to minimize fiber dedifferentiation
However, some issues remain unresolved, such as the dedifferentiation
which occurs in cultured chondrocytes in vitro.
The term dedifferentiation
was first coined by Dahlin and Beabout  in their description of a peculiar clinicopathological entity of a chondrosarcoma , which was later established in salivary gland neoplasms .
A mechanism of "dedifferentiation
" of lymphoma cells into more immature stages as a result of secondary genetic events has been suggested in our case.
Additionally, spindle or tubular predominance and low to high grades including sarcomatoid dedifferentiation
can be observed with impact on the aggressiveness of the clinical course [2,3].
Stem cell activation and scarless wound healing are considered to be essential requisites for quality tissue regeneration [16-18]; however, for some regenerative processes a dedifferentiation
process, but not stem cell activation, is required .
In previous studies, we have shown that the dedifferentiation
process is relatively independent of the fat depot, obesity level, sex, or age of the cell donor .
Furthermore, during dedifferentiation
, or upon induction of pluripotency, mitochondrial morphology reverts to that of stem cells displaying immature spherical and cristae-poor structures [11, 12], and, in itself, promotion of glycolysis at the expense of oxidative phosphorylation promotes dedifferentiation