dedifferentiated


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Related to dedifferentiated: dedifferentiated liposarcoma

dedifferentiated

Referring to a cell or tissue which has acquired a less mature appearance and metabolic profile, an event classically associated with aggressive malignancies.
References in periodicals archive ?
Dedifferentiated chordoma, meanwhile, is a fatal variant of conventional chordoma that is even rarer, occurring in only 2%-8% of all chordomas.
Locoregional disease patterns in well-differentiated and dedifferentiated retroperitoneal liposarcoma: Implications for the extent of resection?
The dedifferentiated myoepithelial cells undergo condensation of their myofilaments into SLSs.
In contrast, well-differentiated or dedifferentiated liposarcomas display amplifications of chromosome locus 12q13-15, and contain several amplified genes including MDM2, CPM, CDK4, and TSPAN 31.
Dedifferentiated and pleomorphic liposarcomas have a propensity to be more aggressive and have a less favourable prognosis with regards to local recurrence and distant metastasis than well-differentiated liposarcoma.
In a subgroup analysis of liposarcomas, there was no statistically significant impact on OS for patients undergoing radiation with either well-differentiated or dedifferentiated liposarcomas.
According to World Health Organization, it is classified into four subtypes: Atypical Lipomatous Neoplasm/ Well Differentiated Liposarcoma, Myxoid/Round cell, Dedifferentiated and Pleomorphic liposarcoma.
* The variant type can be subclassified into four forms: dedifferentiated, mesenchymal, clear-cell, and myxoid.
The board agreed it was reasonable to conduct surveillance screening due to the anatomical location and the tumor being well differentiated with only a small amount of dedifferentiated tumor present.
Cha, "Multipotent, dedifferentiated cancer stem-like cells from brain gliomas," Stem Cells and Development, vol.
Multitabbed online browsing, which homologizes a heterogeneous glut of data into an operational plane of experience, yielding noise (pop-up advertisements being the most obvious example) in tandem with informed content, might be one interface through which to effectively cohere Bader's "Images." Given its extensively dedifferentiated organizational structure, this is an exhibition to navigate like one's morning e-mails.
The luminal epithelium consists of irregularly shaped dedifferentiated cells connected by apically located zonulae adhae-rentes (Fig.