dedifferentiated


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Related to dedifferentiated: dedifferentiated liposarcoma

dedifferentiated

Referring to a cell or tissue which has acquired a less mature appearance and metabolic profile, an event classically associated with aggressive malignancies.
References in periodicals archive ?
1] Dedifferentiated liposarcoma is a relatively new tumour introduced by Evans in 1979.
1,2,17] In undifferentiated carcinomas vimentin is still reactive because, as the cells become dedifferentiated, they lose the characteristics of the origin tissue.
In a kidney biopsy study of 74 patients with CKD from various aetiologies, KIM-1 was primarily expressed at the luminal side of dedifferentiated proximal tubules, in areas with fibrosis and inflammation [6].
Juvenile tissues of woody plants tend to have higher levels of endogenous auxin and are less differentiated and therefore more prone to dedifferentiated [26,10].
Pathological and radiological differential diagnosis Small round blue cell tumour Radiological Non-Hodgkin's lymphoma Rhabdomyosarcoma Rhabdomyosarcoma Myosarcoma Small cell lung cancer Malignant fibrous Merkel cell cancer histiocytoma (MFH) Haemangiopericytoma Dedifferentiated liposarcoma Neuroblastoma Ewing's sarcoma Ewing's sarcoma Primitive neuro-ectodermal tumour (PNET)
Peripheral Ameloblastic carcinomas may arise de novo and as dedifferentiated Ameloblastic carcinomas from pre existing benign peripheral ameloblastomas.
They became dedifferentiated "Jews," and their mousification, attended by the corresponding catification of the Germans, provides a means of depicting the pervasive sway of those racialist mantles.
The remaining 2 patients had histological diagnoses of periosteal osteosarcoma and dedifferentiated parosteal osteosarcoma respectively.
Cancer cells are dedifferentiated, meaning they lose the specialisations of the tissue from which they originate, so, as they enlarge and displace normal cells, tissue function is lost.
Based on certain changes in the cells, we were able to see that almost all heart muscle cells had been dedifferentiated within six days of treatment with oncostatin M," Braun said.
The method the group used, called Transcriptome Induced Phenotype Remodeling, or TIPeR, is distinct from the induced pluripotent stem cell (iPS) approach used by many labs in that host cells do not have to be dedifferentiated to a pluripotent state and then redifferentiated with growth factors to the destination cell type.