dedifferentiation

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Related to dedifferentiate: redifferentiation

anaplasia

 [an″ah-pla´zhah]
loss of differentiation of cells and their orientation to each other, a characteristic of tumor cells; called also dedifferentiation and undifferentiation.

de·dif·fer·en·ti·a·tion

(dē-dif'ĕr-en'shē-ā'shŭn),
1. The return of parts to a more homogeneous state.
2. Synonym(s): anaplasia

dedifferentiation

/de·dif·fer·en·ti·a·tion/ (de-dif″er-en″she-a´shun) anaplasia.

dedifferentiation

(dē′dĭf-ə-rĕn′shē-ā′shən)
n. Biology
Reversion of a specialized cell or tissue to an unspecialized form. Dedifferentiation may occur before the regeneration of appendages in plants and certain animals and in the development of some cancers.

de′dif·fer·en′ti·ate′ v.

dedifferentiation

See anaplasia.

dedifferentiation

Pathology
The reversion of a cell or cell line to a more embryonic form.
 
Tumour biology
The loss of the cellular features of terminal differentiation, a finding often associated with increased aggressiveness of a neoplasm.

de·dif·fer·en·ti·a·tion

(dē-dif'ĕr-en'shē-ā'shŭn)
1. The return of parts to a more homogeneous state.
2. Synonym(s): anaplasia.

dedifferentiation

a process in which tissues that have undergone CELL DIFFERENTIATION can be made to reverse the process so as to become a primordial cell again (see GURDON). In theory, all cells should possess this ability since the mature cell does not lose DNA (see TOTIPOTENCY), but reversal has been demonstrated in plants much more easily than in animal cells.

dedifferentiation

regression from a more specialized or complex form to a simpler state.
References in periodicals archive ?
Taken together, the available data suggest that the extraordinary regenerative potential of holothurian visceral organs is mostly due to the ability of specialized cells to dedifferentiate and rebuild the lost structures through proliferation and migration.
He and his colleagues have recently shown that some factor present in blood serum, newt or any other kind, can induce newt muscle cells to dedifferentiate.
Prior to migration, the cells seem to dedifferentiate.
During the process of regeneration, these cells appeared to dedifferentiate into mesenchymal-like cells and then to redifferentiate into new types of cells that later gave rise to the regenerated structures (Thorndyke et at.
After settlement, the larval flagellated cells dedifferentiate into a simple cell mass on the substratum; thereafter they differentiate again into the three principal cell types of a juvenile sponge.
Reprogramming human somatic cells to dedifferentiate them back into pluripotent stem cells is a key proposal in the 2005 President's Council on Bioethics white paper Alternative Sources of Human Pluripotent Stem Cells.
permollis, the highly differentiated flagellated cells of larvae dedifferentiate to amoeboid cells that subsequently differentiate to choanocytes in juveniles.
Extensive extramedullary disease in myeloma: an uncommon variant with features of poor prognosis and dedifferentiate.
Indeed, this has led some experts to consider STUMP to be within the spectrum of BPH, (10) although most agree that it is a distinct entity as it often rapidly recurs, is seen in younger men, occurs in the peripheral zone, may infiltrate locally, and may dedifferentiate to or coexist with stromal sarcoma.
Cellular origin of cancer: dedifferentiate or stem cell maturation arrest?