CLEC6A

(redirected from dectin-2)

CLEC6A

A gene on chromosome 12p13 that encodes a C-type lectin domain protein involved in Ca2+-dependent binding of high-mannose carbohydrates present on the surface of Candida albicans, dust mites and Schistosoma mansoni eggs, altering the adaptive immune response.
References in periodicals archive ?
Neither dectin-2 nor the mannose receptor is required for resistance to Coccidioides immitis in mice.
The major PRRs involved in fungal immune responses are C-type lectin receptors Dectin-1, DC-SIGN, Dectin-2, Mincle, Galectin-3 and Mannose Receptor.
Important exam-ples include MBL, SP-A and SP-D, class A scavenger receptors such as MARCO (macrophage receptor with a collagenous structure), and dectin-1 and dectin-2.
Dectin-2 recognizes high-mannose structures 85),86) and induces cytokine production by signaling through an Fc receptor .
2006) Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses.
2006) The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose.
This led us to believe that the dectin-2 promoter might direct expression of other genes to Langerhan's cells," Dr.
Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses.