The scientists found that the receptor,
dectin-1, recognises a protein found in house dust mites, cockroaches, shellfish and other invertebrates, and responds by suppressing immune reactions to these common triggers of allergy and asthma.
Prebiotics in addition to the previously mentioned benefits are known to improve absorption and immune modulation in the target species (Sang & Fotedar 2010) which is mediated as a result of direct interaction with its receptors which include [beta]-glucan receptors and
dectin-1 receptors.
beta]-glucans act on a variety of receptors in the immune system, particularly on CR3 and
Dectin-1, thereby triggering a broad spectrum of immune responses [26].
TLR2, TLR4 and
Dectin-1 signaling in hematopoietic stem and progenitor cells determines the antifungal phenotype of the macrophages they produce," Microbes and Infection, 2016; 18 (5): 354 DOI: 10.
Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1[sz] via a noncanonical caspase-8 inflammasome.
Activation of the innate immune receptor
Dectin-1 upon formation of a 'phagocytic synapse'.
It has been shown that Th17 cells can be converted to Thl cells or Th2 cells under the influence of interleukin-12 or interleukm-4 respectively, while CD4+, CD25+,forkhead box P3 (Foxp3+) regulatory T-cells can be converted to an interleukin-17-producing cell when co-cultured with dendritic cells selectively activated via
dectin-1.
Nutramunity binds to Complement receptors (CR3), Toll-like receptors (TLRs) and
Dectin-1 receptors found on various immune cells such as monocytes, macrophages, dendritic cells, neutrophils and natural killer cells.
In this study, phagocytosis via the receptor
dectin-1 acted as a sensor of microbe size and prevented NET release by downregulating the translocation of neutrophil elastase to the nucleus [58].
Ficus carica polysaccharides promote DC maturation and function through the
dectin-1 pathway (Tian et al.
The major PRRs involved in fungal immune responses are C-type lectin receptors
Dectin-1, DC-SIGN, Dectin-2, Mincle, Galectin-3 and Mannose Receptor.
The water soluble [beta]-glucans are known to stimulate host immune function by activating
dectin-1 receptors expressed on the cell surfaces of monocytes, macrophages and neutrophils (Brown and Gordon, 2005; Volman et al.
