"While identification of decorin
as a prospective ASC marker makes a step toward stem cell targeting applications, cell surface molecules differentially expressed on pro genitor cells in other organs are yet to be identified," the authors wrote.
Relationships between transforming growth factor-beta1, myostatin, and decorin
: Implications for skeletal muscle fibrosis.
Using tBLASTn, we queried the Nematostella genome with human SLRP proteins (decorin
, biglycan, fibromodulin, lu-mican, keratocan, PRELP, opticin, osteoglycin, and chon-droadherin).
Ruoslahti discovered the use of decorin
for binding and down-regulating the growth factor, TGF-B, which is known to promote scar tissue formation and fibrosis.
Deficient expression of decorin
in infantile progeroid patients.
There have been a number of promising candidate agents that target TGFP and have shown promise in pre-clinical and early phase trials, including pirfenidone, RGTA and decorin
These include the subgroup lecticans (comprising aggrecan, brevican, versican, and neurocan), small leucine-rich proteoglycans (including biglycan and decorin
), phosphacan/ receptor-type-protein-tyrosine phosphatase [beta] (RPTP[beta]), and other proteoglycans, including NG2 and neuroglycanC .
Humphreys-Beher, "Aberrant proteolytic digestion of biglycan and decorin
by saliva and exocrine gland lysates from the N0D mouse model for autoimmune exocrinopathy," Clinical and Experimental Rheumatology, vol.
inhibits angiogenic potential of choroid-retinal endothelial cells by downregulating hypoxia-induced Met, Rac1, HIF-1alpha and VEGF expression in cocultured retinal pigment epithelial cells," Experimental Eye Research, vol.
Krieg, "Effect of interleukin-10 on the gene expression of type I collagen, fibronectin, and decorin
in human skin fibroblasts: differential regulation by transforming growth factor-beta and monocyte chemoattractant protein-1," Biochemical and Biophysical Research Communications, vol.
Lodillinsky et al., "An essential role for decorin
in bladder cancer invasiveness," EMBO Molecular Medicine, vol.
Cui et al., "Expression of decorin
, biglycan, and collagen type I in human renal fibrosing disease," Kidney International, vol.