Debulking nephrectomy | definition of debulking nephrectomy by Medical dictionary
debulking nephrectomy The excision of a kidney with renal cell carcinoma which has already metastasised. Post-metastasis debulking nephrectomies have been shown to improve survival; interferon therapy for such cases may not further improve survival.
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References in periodicals archive
The burden of RCC is increasing across the world, including Pakistan.12 Our phase-I trial had showed that metastatic renal cell carcinoma (mRCC) was the third commonest urologic malignancy in our hospital following bladder and prostate cancers.13 Debulking nephrectomy
and immunotherapy are still the common treatments for such patients.
It is likely that debulking nephrectomy
leads to a significant decrease in circulating immunosuppressive molecules and allows the immune system to mount a temporary response contributing to improved survival in some patients.