Two different pathways generally mediate Apoptosis: intrinsic pathway and extrinsic cell death pathway
. In extrinsic pathway, cell death occurs when activated caspase-8 binds with Fas-associated protein with death domain (FADD), resulting in activation of caspases-6,-9, and ultimately caspase-3 7.
Caspase-Independent Cell Death Pathway
. Caspase-independent apoptotic pathway is also involved in the hair cell loss.
found that cerebral ischemia in mice in the absence of apoptotic signaling is contributing to the nonapoptotic death pathway
Annexin V-FTIC apoptosis detection assay with PI was used to assess the cell death pathway
. The maximum levels of apoptotic and necrotic induction were 4.02 and 2.25 fold, respectively.
The research team found that IFITM3 normally stops multiplication of the virus in human cells at an early step, preventing the infected cells from "implosive" cell death.Therefore, drugs that block this cell death pathway
might be helpful for preventing the effects of ZIKV infection during pregnancy.
The objectives of this study were to investigate effects of apigenin on HeLa, SiHa, CaSki, C33A, and HaCaT cells with respect to (i) cell cytotoxicity, migration, and invasion of those cells; (ii) cell death pathway
and cellular oxidative stress.
Conclusion: In respect to stenodactylin cytotoxicity, our results: (i) confirm the high toxicity to nervous cells, (ii) indicate that multiple cell death pathways
can be induced, (iii) show that apoptosis is the main death pathway
, (iv) demonstrate the involvement of necroptosis and (v) oxidative stress.
"By preventing cell-to-cell transmission, we may able to block the death pathway
and stop the progression from HIV infection to AIDS."
The combination of RAD001 and MK-2206 exerts synergistic cytotoxic effects against PTEN mutant gastric cancer cells: Involvement of MAPK-dependent autophagic, but not apoptotic cell death pathway
. PLoS One 2014;9:e85116.
Nagata, "Necrotic death pathway
in Fas receptor signaling," Journal of Cell Biology, vol.
If they plan to bring elderly relatives over, would they want them placed on the fast-track, stairway-to-heaven Liverpool Death Pathway
as soon as they developed dementia, like 20,000 other sufferers each year?