death pathway

death pathway

finding that characterizes a protein that initiates final stage of cell death known as apoptosis. Mammalian families of proteins that execute the apoptotic pathway are Bcl-2, Apaf-1, and caspase-3. FAS receptor-ligand system is a regulator of apoptotic cell death.
Synonym(s): cell-death pathway
References in periodicals archive ?
Therefore, drugs that block this cell death pathway might be helpful for preventing the effects of ZIKV infection during pregnancy.
By preventing cell-to-cell transmission, we may able to block the death pathway and stop the progression from HIV infection to AIDS.
If they plan to bring elderly relatives over, would they want them placed on the fast-track, stairway-to-heaven Liverpool Death Pathway as soon as they developed dementia, like 20,000 other sufferers each year?
Prof Patrick Pullicino, a consultant neurologist, told the Daily Mail: "The lack of evidence for initiating the Liverpool Care Pathway makes it an assisted death pathway rather than a care pathway.
It is reported that NDV induces expression of various cytokines which can activate host cell death pathway causing oncolysis.
Preclinical studies suggest that TREANDA may lead to cell death by a process known as apoptosis (programmed cell death) as well as by an alternate cell death pathway which disrupts normal cell division known as mitotic catastrophe (a non-apoptotic pathway).
Therefore, JNK is required for stress-induced activation of the cytochrome c-mediated death pathway (Tournier et al.
This dephosphorylation relieves repression, allowing genes in a death pathway to be transcribed, leading to lysis of the bacteria.
We are all looking for a unifying theme that might funnel all these different models into a common death pathway," says Hockenbery, He and his co-workers speculate that - no matter what the specific death signal or cell type - once a cell is bent on dying, it does so via free radicals, turning loose a chain of ruinous chemical reactions that bcl-2 can counter.
Conclusion: In respect to stenodactylin cytotoxicity, our results: (i) confirm the high toxicity to nervous cells, (ii) indicate that multiple cell death pathways can be induced, (iii) show that apoptosis is the main death pathway, (iv) demonstrate the involvement of necroptosis and (v) oxidative stress.
The induction of apoptotic cell death pathway was further confirmed at protein level by western blot analysis of PARP fragmentation.