PIA biosynthesis is carried out by the proteins encoded by the ica gene operon: N-acetylglucosamine transferase (icaA and icaD), PIA deacylase
(icaB), PIA exporter (icaC) and the regulatory gene (icaR) [12 13].
Miller, "3-O-deacylation of lipid A by PagL, a PhoP/PhoQ-regulated deacylase
of Salmonella typhimurium, modulates signaling through Toll-like receptor 4," Journal of Biological Chemistry, vol.
Nishijima, "Release of the lipopolysaccharide deacylase
PagL from latency compensates for a lack of lipopolysaccharide aminoarabinose modification-dependent resistance to the antimicrobial peptide polymyxin B in Salmonella enterica," Journal of Bacteriology, vol.
After transfer, the inositol group introduced before mannosylation of the GPI precursor is removed in humans and yeast by the orthologous PGAP1/Bst1 deacylase
ER proteins .
inhibitors: Induction of differentiation of ATRA-resistant APL with PLZF-RAR[alpha], using combination of pharmacological dose of ATRA and HDAC inhibitors (TSA or sodium phenylbutyrate) opened a new avenue in the treatment of not only APL but also AML1-ETO AML .
High expression of sphingomyelin deacylase
is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis.
Filaggrin deficiency appears to lead to impaired barrier function and a reduction in the activity of one of the key enzymes involved in bilayer formation, sphingomyelin deacylase
, leading to reduced ceramide levels and altered lipid packaging.
The speaker also detailed the role that sphingomyelin (SM) deacylase
, an epidermal enzyme, plays in the barrier disruption in atopic dermatitis.
SIRT1 (silent information regulator 2 (Sir2) protein 1) is a sirtuin possessing histone deacylase
activity and it plays a role in the hormetic response of cells to oxidative stressors.
Leo, "Sirtuin deacylases
: a molecular link between metabolism and immunity," Journal of Leukocyte Biology, vol.
Hirschey, "Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases
," Molecular Cell, vol.
Although all sirtuins are classified as deacetylases, Sirt4 and Sirt5 have weak deacetylase activity and function as demalonylases and deacylases
[22, 23] (Figure 1).