deacylase

de·ac·yl·ase

(dē-as'il-ās),
1. A member of the subclass of hydrolases (EC class 3), especially of that subclass of esterases, lipases, lactonases, and hydrolases (EC subclass 3.1).
2. Any enzyme catalyzing the hydrolytic cleavage of an acyl group (R-CO-) in an ester linkage; also includes enzymes cleaving amide linkages (EC subclass 3.5) and similar acyl compounds.
Farlex Partner Medical Dictionary © Farlex 2012

de·ac·yl·ase

(dē-as'il-ās)
1. A member of the subclass of hydrolases (EC class 3), especially of that subclass of esterases, lipases, lactonases, and hydrolases (EC subclass 3.1).
2. Any enzyme catalyzing the hydrolytic cleavage of an acyl group (R-CO-) in an ester linkage; also includes enzymes cleaving amide linkages (EC subclass 3.5) and similar acyl compounds.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
PIA biosynthesis is carried out by the proteins encoded by the ica gene operon: N-acetylglucosamine transferase (icaA and icaD), PIA deacylase (icaB), PIA exporter (icaC) and the regulatory gene (icaR) [12 13].
Miller, "3-O-deacylation of lipid A by PagL, a PhoP/PhoQ-regulated deacylase of Salmonella typhimurium, modulates signaling through Toll-like receptor 4," Journal of Biological Chemistry, vol.
Nishijima, "Release of the lipopolysaccharide deacylase PagL from latency compensates for a lack of lipopolysaccharide aminoarabinose modification-dependent resistance to the antimicrobial peptide polymyxin B in Salmonella enterica," Journal of Bacteriology, vol.
After transfer, the inositol group introduced before mannosylation of the GPI precursor is removed in humans and yeast by the orthologous PGAP1/Bst1 deacylase ER proteins [127].
Histone deacylase inhibitors: Induction of differentiation of ATRA-resistant APL with PLZF-RAR[alpha], using combination of pharmacological dose of ATRA and HDAC inhibitors (TSA or sodium phenylbutyrate) opened a new avenue in the treatment of not only APL but also AML1-ETO AML [36].
High expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis.
Filaggrin deficiency appears to lead to impaired barrier function and a reduction in the activity of one of the key enzymes involved in bilayer formation, sphingomyelin deacylase, leading to reduced ceramide levels and altered lipid packaging.
The speaker also detailed the role that sphingomyelin (SM) deacylase, an epidermal enzyme, plays in the barrier disruption in atopic dermatitis.
SIRT1 (silent information regulator 2 (Sir2) protein 1) is a sirtuin possessing histone deacylase activity and it plays a role in the hormetic response of cells to oxidative stressors.
Leo, "Sirtuin deacylases: a molecular link between metabolism and immunity," Journal of Leukocyte Biology, vol.
Hirschey, "Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases," Molecular Cell, vol.
Although all sirtuins are classified as deacetylases, Sirt4 and Sirt5 have weak deacetylase activity and function as demalonylases and deacylases [22, 23] (Figure 1).

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