daunorubicin


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Related to daunorubicin: doxorubicin

daunorubicin

 [daw″no-roo´bĭ-sin]
an antitumor antibiotic of the anthracycline family, produced by a strain of Streptomyces coeruleorubidus and having antimitotic, cytotoxic, and immunosuppressive effects. As the hydrochloride salt it is administered intravenously in the treatment of acute lymphoblastic leukemia and acute myelogenous leukemia. As a liposome-encapsulated preparation of the citrate salt, it is administered intravenously in the treatment of advanced Kaposi's sarcoma associated with acquired immunodeficiency syndrome (AIDS).

dau·no·ru·bi·cin

(daw'nō-rū'bi-sin),
An antineoplastic antibiotic of the rhodomycin group, obtained from Streptomyces peucetius.

daunorubicin

/dau·no·ru·bi·cin/ (daw″no-roo´bĭ-sin) an anthracycline (q.v.) antibiotic used as an antineoplastic; administered as the hydrochloride salt or as a liposome-encapsulated preparation of the citrate salt.

daunorubicin

Oncology An antineoplastic antibiotic isolated from Streptomyces spp, effective against ALL and AML, and used for other CAs Toxicity Dose-related BM suppression, mucositis, alopecia, severe local reaction with extravasation

ru·bid·o·my·cin

(rū-bid'ō-mī'sin)
An antibiotic used as an antineoplastic; similar to doxorubicin in antitumor activity and in exhibiting cumulative cardiotoxicity.
Synonym(s): daunorubicin.

daunorubicin

An antibiotic drug used in the consolidation phase of the treatment of acute leukaemia. The drug is on the WHO official list. Brand names are Cerubidin and Daunoxome.

dau·no·ru·bi·cin

(daw'nō-rū'bi-sin)
An anti neoplastic antibiotic of the rhodomycin group, obtained from Streptomyces peucetius.

daunorubicin

an anthracycline antibiotic produced by a strain of Streptomyces coeruleorubidus that is closely related to doxorubicin and has antimitotic, cytotoxic and immunosuppressive effects.
References in periodicals archive ?
Isolation and characterization of stable mutants of Streptomyces peucetius defective in daunorubicin biosynthesis.
The scientists bound the surfaces of nanodiamonds with Daunorubicin, and the hybrid nanodiamond-drug complexes were introduced to leukemic cells.
The cancer therapy agents vincristine and daunorubicin have a toxic effect on the mucosa [Kostler et al.
He was enrolled in a treatment protocol employing three days of daunorubicin, seven days of continuous infusion cytarabine, and one dose of gemtuzumab ozogamicin (Mylotarg[R]).
After achieving remission, two cycles of consolidation, each of 28 days, consisting of daunorubicin in the same dose on days 1, 2 and 3 were given.
The drugs and their final concentrations (1:50) used in this study were as follows: cytarabine (AraC), 10 and 100 [micro]mol/L; daunorubicin (DNR), 0.
Furthermore anticicatricial agents were also used such as daunorubicin, bleomycin, mitramycin, 5-fluoracil, cyanoacrylate and mitomycin C (LEE et al.
Toremifene CYP3A4 Active Induction: [up arrow] efficacy Inhibition: [up arrow] risk of adverse effects Glucocorticoids CYP3A4 Inhibitors: CYP3A4 inducer [up arrow] risk corticosteroid -related toxicity Inducers: [down arrow] efficacy Reduces efficacy of CYP3A4 substrates Table IV Anticancer drugs that are p-glycoprotein substrates Clilorambucil Etoposide Cisplatin Methylprednisolone Dactinomycin Mitoxantrone Daunorubicin Paclitaxel Dexamethasone Tamoxifen Docetaxel Vinblastine Doxorubicin Vincristine
To date she has received two courses of cytarabine (ara-c) and daunorubicin therapy, which were tolerated well, and is awaiting her third course.
The anthracycline daunorubicin (D1) is converted to daunorubicinol (D2) in older rats.