daunomycin


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daunomycin

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Anthracycline antibiotics, primarily daunomycin and adriamycin, have been utilized in clinical practice since the 1960's and represent one of the most commonly used classes of anticancer drugs against leukemias and solid tissue tumors (reviewed by Sinha & Politi 1990; Hande 1998; Gewirtz 1999; Ogura 2001; Felix 2001).
Previous studies in this laboratory have shown that daunomycin can induce both frameshift and base-substitution transition mutations in Salmonella typhimurium (Mackay et al.
This report describes the use of a disposable (using thick-film technology) electrochemical DNA sensor (carbon electrode with an immobilized oligonucleotide on the surface and daunomycin as electrochemical indicator) coupled with PCR amplification of DNA extracted from human blood for the genetic detection of apolipoprotein E (apoE) (3) polymorphism.
The probe is then immersed in the daunomycin solution, which intercalates the hybrid formed on the electrode surface.
Other drugs have included: Daunomycin, Adriamycin, Nybomycin Acetate, Dermostatin A and Dermostatin B.
Interestingly, adriamycin, unlike daunomycin, did not induce AT to GC (TA7001) events in this assay.
The anthracycline antibiotics adriamycin and daunomycin have been in use for more than thirty years and are among the most widely used in cancer chemotherapy.
Drugs such as daunomycin and doxorubicin may also lead to cardiomyopathy through increased ROS generation [9].
Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin.
For example, anthracyclines such as daunomycin have been loaded into lipoproteins and their distribution in plasma proteins has been studied [10].
This study examined the mutagenic effects of the anthracycline daunomycin in a new set of Salmonella strains.
Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a nonimmunosuppressive cyclosporin derivative.