daunorubicin

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daunorubicin

 [daw″no-roo´bĭ-sin]
an antitumor antibiotic of the anthracycline family, produced by a strain of Streptomyces coeruleorubidus and having antimitotic, cytotoxic, and immunosuppressive effects. As the hydrochloride salt it is administered intravenously in the treatment of acute lymphoblastic leukemia and acute myelogenous leukemia. As a liposome-encapsulated preparation of the citrate salt, it is administered intravenously in the treatment of advanced Kaposi's sarcoma associated with acquired immunodeficiency syndrome (AIDS).

dau·no·ru·bi·cin

(daw'nō-rū'bi-sin),
An antineoplastic antibiotic of the rhodomycin group, obtained from Streptomyces peucetius.

daunorubicin

Oncology An antineoplastic antibiotic isolated from Streptomyces spp, effective against ALL and AML, and used for other CAs Toxicity Dose-related BM suppression, mucositis, alopecia, severe local reaction with extravasation

ru·bid·o·my·cin

(rū-bid'ō-mī'sin)
An antibiotic used as an antineoplastic; similar to doxorubicin in antitumor activity and in exhibiting cumulative cardiotoxicity.
Synonym(s): daunorubicin.

daunorubicin

An antibiotic drug used in the consolidation phase of the treatment of acute leukaemia. The drug is on the WHO official list. Brand names are Cerubidin and Daunoxome.

dau·no·ru·bi·cin

(daw'nō-rū'bi-sin)
An anti neoplastic antibiotic of the rhodomycin group, obtained from Streptomyces peucetius.
References in periodicals archive ?
Caption: Figure 4: FTIR spectra of avidin-immobilized magnetic nanoparticles (a), daunomycin (b), and iminobiotinylated daunomycin-loaded magnetic nanoparticles (c).
Induction phase over 4 weeks included 4 drugs namely vincristine 1.5gm/m2 weekly, oral prednisolone 60mg/m2 daily, L-asparaginase 2500 IU/m2 (9 doses) and daunomycin 25mg/m2 weekly with intrathecal methotrexate on day 1, 15 and 28.
Typical examples are the aromatic anthracycline antibiotics (daunomycin, doxorubicin, topotecan, mitoxantrone, etc.), which are effective against solid tumors and leukemia; quinolone antibiotics (norfloxacin, ofloxacin, etc.), exerting a wide spectrum of antibacterial activity; aromatic vitamins (riboflavin, nicotinamide, etc.), used as antioxidants in chemotherapy; methylxanthines which are present in high concentrations in food sources; and many other aromatic compounds, possessing useful medicobiological properties (Figure 1) [1,2].
Recently published preclinical reports indicate that SMN increased the uptake and provoked the action of chemotherapeutic chemicals of daunomycin and doxorubicin, respectively.
(1991) Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells.
Certain chemotherapy agents--such as doxombicin, daunomycin and cyclophosphamide --may be toxic to the myocardium.
"One-electron reduction of daunomycin, daunomycinone, and 7- deoxydaunomycinone by the xanthine/xanthine oxidase system: detection of 16 semiquinone free radicals by electron spin resonance," Journal of the American Chemical Society, Vol.109, pp.348-51.
Potentiation of the biological activities of daunomycin and Adriamycin by ascorbic acid and dimethylsulfoxide.
Although 94% knew they had chemotherapy, fewer could name chemotherapy drugs such as doxorubicin (52%) and daunomycin (30%).
P List (a) U List (b) Epinephrine (adrenaline) P042 Chlorambucil (Leukeran) U035 Nicotine P075 Cyclophosphamide (Cytoxan, Neosar, Procytox) U058 Nitroglycerine P081 Daunomycin (Dauorubicin, Cerubidine) U059 Physostigmine P204 Diethylstilbestrol U089 Physostigmine salicylate P188 Melphalan (Alkeran) U150 Warfarin > 0.3% P001 Mitomycin C (Mutamycin) U010 Paraldehyde U182 Phenacetin U187 Reserpine U200 Saccharin U202 Selenium sulfide U205 (e.g., dandruff shampoos) Streptozocin (Zanosar) U206 Uracil mustard U237 Warfarin (Coumadin) < 0.3% U248 (a) Representative P-listed drugs (some have other uses).