Other research groups had concluded that p63 is essential for the maturation of the daughter cells
, not for the maintenance of the stem cell lineage.
Surprisingly, the team observed that such confinement resulted in the abnormal division of a single cancer cell into three or four daughter cells
at a much higher rate than typical.
However, the factors that drive daughter cells
to be identical or different remain poorly understood by scientists.
But how the production of daughter cells
from the different stem cell types is coordinated within a single niche is virtually unknown.
After analyzing the videotapes, Stewart's team found that daughter cells
aren't as alike as they look.
Citation: Pekka Katajisto et al.; "Asymmetric apportioning of aged mitochondria between daughter cells
is required for stemness"; Science, 2015; DOI: 10.1126/science.1260384
The researchers point out that two daughter cells
arise from a single sensory organ precursor mother cell in the fly peripheral nervous system, and that among the daughter cells
, Notch is activated in one and not in the other.
When bound to one region, EBNA1 helps initiate replication of the viral episome and the dispersal of the two copies into the daughter cells
. When bound to the other region, however, EBNA1 somehow protects the viral DNA from being eliminated by the cell.
Initial evaluation for PD-L1 protein expression changes focused on comparisons between the parental HCC827 cells and a group of daughter cell
lines with acquired resistance to EGFR-TKIs.
When young brain stem cells split in two, they wall off damaged proteins in one daughter cell
, leaving the other spry and ready to divide again, researchers report in the Sept.
The daughter cell
is smaller than the mother, therefore we can recognize which is the daughter cell
after budding (Fig.
We tend to assume that when single-celled organisms divide asexually, they produce two identical daughter cells
. But when diatoms divide, they produce one daughter cell
that is slightly smaller than its sister.