dapsone


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dapsone

 [dap´sōn]
an antibacterial used in treatment of leprosy and dermatitis herpetiformis and for prophylaxis of malaria caused by Plasmodium falciparum. Called also DDS.

dap·sone

(dap'sōn),
An antibiotic used to treat leprosy and certain cutaneous diseases such as dermatitis herpetiformis, is active against the tubercle bacillus, is used in the treatment of bovine coccidiosis and streptococcal mastitis, and is used as a second-line agent in Pneumocystis jiroveci [carinii] pneumonia.

dapsone

(dăp′sōn′, -zōn′)
n.
A sulfone drug, C12H12N2O2S, that is used primarily to treat leprosy and some forms of dermatitis.

dap·sone

(dap'sōn)
An antibiotic used to treat leprosy and cutaneous diseases such as dermatitis herpetiformis; active against the tubercle bacillus; used in the treatment of bovine coccidiosis and streptococcal mastitis and as a second-line agent in Pneumocystis jiroveci [carinii] pneumonia.

dapsone

Diaminodiphenyl sulfone. For many years this has been the standard drug to treat leprosy, but irregular use has led to the development of drug resistance. Dapsone is also used in the treatment of DERMATITIS HERPETIFORMIS which may be associated with COELIAC DISEASE.

dap·sone

(dap'sōn)
Antibiotic used to treat leprosy; active against the tubercle bacillus; used as a second-line agent in Pneumocystis jiroveci (carinii) pneumonia.
References in periodicals archive ?
The mechanism of action of dapsone is most likely related to its duality to act as a chemotherapeutic agent as well as anti-inflammatory.
Dapsone resistance might not necessarily have clinical significance when patients take multidrug therapy as recommended by the World Health Organization.
Dapsone and sulfones in dermatology: Overview and update.
In the study, the recurrences were majorly observed in type 2 reaction patients rather than type 1 reaction, patients with G6PD deficiency who were not started on with the Dapsone therapy showed maximum number of recurrences even after starting on rest of the standard WHO therapy.
Irwanto et al., "HLA-B* 13:01 and the dapsone hypersensitivity syndrome," The New England Journal of Medicine, vol.
Thalidomide shows immunomodulatory activity through suppression of tumour necrosis factor-alpha, basic fibroblast growth factor and neutrophil chemotaxis.10 A study was carried out by Elgart, that included four patients with pyoderma gangrenosum unresponsive to treatment with prednisone, cyclosporin, colchicine, cytoxan, and dapsone. In an open, non-blinded study, all four were treated with thalidomide, with doses up to 200 mg per day.
Between the two antileprosy drugs included in this study, dapsone had better activity than clofazimine, even though clofazimine is a well-known second-line antileprosy drug [26].
The treatment of choice of leprosy is based on rifampicin and dapsone association; clofazimine may be added in the cases of lepromatous leprosy.
[1-5] A case report also had mentioned bullous eruptions during treatment with dapsone. [6]
Non-steroidal anti-inflammatory drugs (NSAIDs), dapsone, colchicine and prednisolone have been used with good effect.
Wardekar (4) reported results from two surveys, but only those 0-25 years of age were allocated to receive dapsone or a placebo, and thus, only this age group was used to estimate the effects of the chemoprophylaxis.
The boy's bullous pemphigoid was being treated with dapsone 50 mg per day and corticoid applications.