DACT1(redirected from dapper homolog 1, antagonist of beta-catenin)
DACT1A gene on chromosome 14q23.1 that encodes a protein which upregulates DVL2-mediated signalling pathways during development. DACT1 binds to DVL2 and impedes CTNNB1/beta-catenin degradation, thereby enhancing transcriptional activation of target genes of the Wnt signalling pathway.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.