danazole

danazole

A synthetic PROGESTOGEN drug that inhibits secretion by the PITUITARY gland of the sex-gland stimulating hormone gonadotrophin. It is used to treat precocious puberty, breast enlargement in the male (gynaecomastia), excessive menstruation (menorrhagia) and ENDOMETRIOSIS. A brand name is Danol.
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However, its inhibitory potential was less potent than that of danazole [[K.sub.i] = 0.02 [micro]M, [12], telmisartan [[K.sub.i] = 0.19 [micro]M [17] and flunarizine [[K.sub.i] = 0.13 [micro]M], and decursin [[K.sub.i] = 8.34 [micro]M, [9].
After treatment with danazole the patient reported a significant decrease in the frequency of attacks and the severity of pain.
Treatment of it with symptomatic a well as dietary modification, evening primerose oil, danazole ect.
Clinically significant interactions have been reported with potent CYP4503A4 inhibitors including cyclosporine, macrolide antibiotics, azole antifungals, protease inhibitors, nefazodone, amiodarone, danazole, diltiazem, and verapamil.