and recombinant hirudin are the common heparin replacements in cases of HIT II, but the former has low-grade cross-reactivity with HIT antibodies and is high in cost, whilst the latter has prolonged half-life and tends to cause antibody formation (Suranyi & Chow, 2010; Unver et al., 2002).
UFH and other LMWHs, such as fondaparinux and danaparoid
, do not possess intrinsic anticoagulant activity but potentiate antithrombin III that inhibits activated coagulation agents .
A diagnosis of thrombophlebitis of the portal vein associated with CCF was made, and the patient was immediately managed with an intravenous broad-spectrum antibiotic (DRPM at 1.5 g/day) and anticoagulation therapy was started (danaparoid
sodium at 2500IU/day).
Itoh et al., "Optimizing risk stratification in portal vein thrombosis after splenectomy and its primary prophylaxis with Antithrombin III concentrates and Danaparoid
sodium in liver cirrhosis with portal hypertension," Journal of the American College of Surgeons, vol.
However, other non-heparin anticoagulants, namely, bivalirudin, fondaparinux, and danaparoid
, have been used successfully.
Looser clot structure has also been shown in the presence of argatroban, bivalirudin, lepirudin, and danaparoid
Treatment of 51 pregnancies with danaparoid
because of heparin intolerance.
was used previously with success, but this product is no longer available.
The present in vitro experiments were planned to determine whether the DTIs lepirudin and argatroban and the predominantly factor Xa inhibitors enoxaparin, danaparoid
, and fondaparinux could interfere with the result of LA testing based on dPT.
Kasabach-Merritt syndrome associated with giant liver hemangioma; the effect of combined therapy with danaparoid
sodium and tranexamic acid.
He was infused large-volume crystalloid fluids and diuretics for HC along with danaparoid
for prevention of clots in the bladder, but his hematuria progressed to grade IV and MGH from day 17.
(11) Because ofthe high rate ofthrombosis in patients with HIT, anticoagulation should be switched from heparin to an alternative anticoagulant; a direct thrombin inhibitor such as lepirudin (recombinant hirudin), bivalirudin, argatroban, fondaparinux, or danaparoid
. Although not formally approved for this indication by the FDA, there are an increasing numbers of anecdotal reports of patients with HIT being successfully managed with the pentasaccharide, fondaparinux, in lieu of a direct thrombin inhibitor (DTI).