dactinomycin


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Related to dactinomycin: Daunorubicin, doxorubicin

dactinomycin

 [dak″tĭ-no-mi´sin]
an antitumor antibiotic of the actinomycin complex (actinomycin D), produced by Streptomyces parvulus. Used to treat rhabdomyosarcoma and Wilms' tumor in children, as well as Ewing's sarcoma, Kaposi's sarcoma, osteogenic sarcoma, soft tissue sarcomas, testicular carcinoma, and choriocarcinoma.

dac·ti·no·my·cin

(dak'ti-nō-mī'sin),
An antineoplastic antibiotic produced by several species of Streptomyces (for example, S. parvulus).
See also: actinomycins.
Synonym(s): actinomycin D

dactinomycin

(dăk′tə-nō-mī′sĭn)
n.
An antibiotic of the actinomycin group, C62H86N12O16, isolated from bacteria and used as an antineoplastic agent in the treatment of certain cancers. Also called actinomycin D.

Actinomycin D

A relatively toxic antibiotic produced by Streptomyces spp, which is used as a chemotherapeutic.
Mechanism Inhibits DNA transcription by RNA polymerase.
Indications Rhabdomyosarcoma, Wilms’ tumour, gestational trophoblastic tumour 
Adverse effects Anorexia, nausea, vomiting, myelosuppression with pancytopenia, diarrhoea

dactinomycin

Oncology An antitumor antibiotic member of a class of drugs first isolated from Streptomyces, and used to treat Wilms' tumor, Ewing sarcoma, embryonal rhabdomyosarcoma, choriocarcinoma, seminoma, KS, lymphoma

dac·ti·no·my·cin

(dak'ti-nō-mī'sin)
An antineoplastic antibiotic produced by several species of Streptomyces (e.g., S. parvulus).

dactinomycin

A cytotoxic drug used to treat cancers mainly of children. Dactinomycin is an antibiotic derived from Streptomyces pavullus which causes breaks in DNA. This side effect renders it unsuitable as an antibacterial drug, but makes it useful as an anti-cancer drug. A brand name is Cosmegen Lyovac. There are other actinomycins in the group produced by Streptomyces chrysomallas .

dac·ti·no·my·cin

(dak'ti-nō-mī'sin)
An antineoplastic antibiotic produced by several species of Streptomyces (e.g., S. parvulus).
References in periodicals archive ?
Efforts are made to reduce these chemotherapy-induced complications by ensuring age-dependent doses of dactinomycin and cyclophosphamide, especially in patients <36 months of age.
Parker RJ, Adamson RH, Douros JD, Sieber SM (1983) Comparative pharmacologic studies of dactinomycin and pip-1-beta actinomycin.
The typical chemotherapeutic agents used are vincristine, dactinomycin, adriamycin, cyclophosphamide, ifosamide and etoposide.[sup.15] The addition of ifosfamide and etoposide has been shown to improve overall survival in patients with non-metastatic skeletal Ewing's sarcoma.[sup.16] Neoadjuvant chemotherapy can improve surgical outcomes and potentially avoid adjuvant radiotherapy, which is often reserved for patients with positive margins after resection or involvement of Gerota's fascia.[sup.17,18]
Patient was started in EMA-CO therapy (Dactinomycin, Ectoposide, Methrotrexate, Cyclophosphamide and Vincristine).
ritonavir): [down arrow] efficacy Inhibition: [up arrow] risk of adverse effects (hot flushes, peripheral oedema, etc.) Toremifene CYP3A4 Active Induction: [up arrow] efficacy Inhibition: [up arrow] risk of adverse effects Glucocorticoids CYP3A4 Inhibitors: CYP3A4 inducer [up arrow] risk corticosteroid -related toxicity Inducers: [down arrow] efficacy Reduces efficacy of CYP3A4 substrates Table IV Anticancer drugs that are p-glycoprotein substrates Clilorambucil Etoposide Cisplatin Methylprednisolone Dactinomycin Mitoxantrone Daunorubicin Paclitaxel Dexamethasone Tamoxifen Docetaxel Vinblastine Doxorubicin Vincristine
2003, mOS with HDCT: 27.1 m retrospective [3] TBI: total body irradiation, HDCT: high-dose chemotherapy, SCT: stem cell transplant, CR: complete response, PR: partial response, EFS: event-free survival, OS: overall survival, V: vincristine, E: etoposide, M: methotrexate, A: dactinomycin, If: ifosfamide, C: cyclophosphamide, D: doxorubicin, T: topotecan, I: irinotecan, Te: temozolomide, Ca: carboplatin, NL: not listed, high I: high-dose ifosfamide, mOS: median overall survival, mRFS: median relapse-free survival, COR: consortium of other regimens, and ONR: outcomes not reported.
Request for quotations: supply of medicinal drug dactinomycin
A randomized trial of etoposide + cisplatin versus vinblastine + bleomycin + cisplatin + cyclophosphamide + dactinomycin in patients with good-prognosis germ cell tumours.
Dactinomycin at 1.25 mg per square meter per dose is substituted for doxorubicin when a total doxorubicin dose of 375 mg per square meter is reached.
Contract awarded for ciprofloxacin 500 mg, tablet, solution for injection fluconazole 2mg / ml vial 100ml (200mg) and actinomycin (dactinomycin) 500 mcg lyophilized powder.
Data from a current COG study evaluating the pharmacokinetics and pharmacogenetics of vincristine and dactinomycin in children (including infants) will help guide the dosing of these agents in future trials 3.