Cordycepin but not D-mannitol or adenosine induces apoptosis in leukemic HL-60 cells
including adenosine, D-mannitol and cordycepin by HPLC analyses.
However, neither adenosine nor D-mannitol caused apoptosis in HL-60 cells, even at high concentration of 100 [micro]g/ml.
Production of the Hexitol d-Mannitol
by cryptococcus neoformans in vitro and in rabbits with experimental meningitis.
However, they showed a positive result for Thornley's arginine dihydrolase test, growth at 28[degrees]C, nitrate reduction, starch degradation, acid production from D-mannitol, use of citrate as sole carbon source, and susceptibility to O/129 (150 [micro]g/disc).
They showed negative responses for ornithine or lysine decarboxylase tests, and positive results for acid production from D-cellobiose, D-mannitol and ribose, use of L-proline as sole carbon source, and growth at 28[degrees]C.
The agreement transfers to zuChem all rights to a worldwide patent portfolio of microbial fermentation methods of producing D-mannitol, a reduced calorie sweetener.
This new microbial process can benefit food companies through the delivery of a consistent, cost-effective supply of D-mannitol.