d-dimer


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Related to d-dimer: d-dimer test

dimer

 
1. a compound formed by combination of two identical simpler molecules.
2. a capsomer having two structural subunits.
D-dimer a fragment of fibrin that is formed as a result of fibrin degradation. A positive test for its presence in the blood is suggestive of conditions such as thrombotic disease, sickle cell crisis, malignancy, disseminated intravascular coagulation, or recent surgery.

d-dimer

a dimer byproduct resulting from fibrinolysis; produced by cross linkage of d-domain fibrin monomers by activated factor XIII, fibrin stabilizing factor; present in low levels in normal animals, but found at particularly high levels in association with thrombotic and hemostatic disorders; assayed as an adjunctive diagnostic tool in conditions such as malignant neoplasia, infectious disease, immune-mediated hemolytic anemia, immune-mediated thrombocytopenia, hyperadrenocorticism, pulmonary thromboembolism, and disseminated intravascular coagulation or DIC. d-dimer production requires both plasmin and thrombin activation. Note that generation of fibrin/fibrinogen degradation products (FDPs) requires only plasmin action on fibrin or fibrinogen. d-dimers clear through urinary excretion, so assay may show falsely increased levels during renal dysfunction. Laboratory ELISA measurement can identify fibrinolysis.

d-dimer

Hematology A fibrin split product that can be used in a sensitive assay of plasmin activity, which is often ↑ in systemic consumptive coagulopathy, ie DIC. See Disseminated intravascular coagulation, Fibrin split products.

d-dimer

A covalently cross-linked degradation product released from the cross-linked fibrin polymer during plasmin-mediated fibrinolysis. Laboratory measurements of this product are made using latex bead assay, or enzyme-linked immunosorbent assay can be used to identify the presence of fibrinolysis; helpful in diagnosis of deep vein thrombosis.

d-dimer

(dī'mer)
A covalently cross-linked degradation product released from the cross-linked fibrin polymer during plasmin-mediated fibrinolysis. Laboratory measurements of this product are made using latex bead assay, or enzyme-linked immunosorbent assay, and can be used to identify the presence of fibrinolysis; helpful in diagnosis of deep vein thrombosis.
References in periodicals archive ?
Analytical performance of the new hemosil d-dimer hs assay that overcomes the rheumatoid factor (RF) interference.
Almost majority of patients (43) had D-dimer positivity.
D-dimer is a fibrin degradation product (or FDP), a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis.
Relative risks per SD of the inflammatory predictors GlycA, hsCRP, IL-6, and D-dimer for the several outcome variables total death, any CVD, ChrIRD, and total cancer are all shown in Table 2.
It should be noted that this study was not performed to evaluate either D-dimer concentration or Well's criteria.
For intermediate-risk patients, the first test to obtain is a highly sensitive D-dimer test.
Positive and negative control plasma samples (for D-dimer test) were supplied with plasma D-dimer kit.
Clinicians were prompted to enter the Wells score and the D-dimer test result, thereby defining the pre-test probability of PE and hence the appropriateness of the CTPA request.
The D-Dimer Assay used for laboratory testing was "D-Dimere Test Innovance" from Siemens.
With regard to coagulopathy, we should consider not only PT, but also FDP, D-dimer, and FIB.
sup][10] Therefore, this study aims to explore diagnostic values of the Wells and revised Geneva scores and their combination with D-dimer, for suspected PE in elderly patients.