cytotoxicity, antibody-dependent cell-mediated

cytotoxicity, antibody-dependent cell-mediated

(sī″tō-tŏk-sĭs′ĭ-tē),

ADCC

The increased ability of natural killer (NK) cells and eosinophils to bind with foreign antigens coated with IgG antibodies and destroy them. When receptors on NK cells bind to the antibody’s Fc fragment, they are stimulated to produce interferon gamma and degranulate, releasing destructive enzymes that kill cells infected with a virus. The presence of antibodies differentiates ADCC from T-cell cytotoxicity, which does not require their presence.
References in periodicals archive ?
Darzalex is believed to induce tumor cell death through multiple immune-mediated mechanisms of action, including complement-dependent cytotoxicity, antibody-dependent cell-mediated cytotoxicity and antibody-dependent cellular phagocytosis, as well as through apoptosis, in which a series of molecular steps in a cell lead to its death.
Daratumumab is believed to induce tumour cell death through multiple immune-mediated mechanisms of action, including complement-dependent cytotoxicity, antibody-dependent cell-mediated cytotoxicity and antibody-dependent cellular phagocytosis, as well as through apoptosis, in which a series of molecular steps in a cell lead to its death.