cytotoxicity


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cytotoxicity

 [si″to-tok-sis´ĭ-te]
1. the degree to which an agent has specific destructive action on certain cells.
2. the possession of such destructive action, particularly in reference to lysis of cells by immune phenomena and to antineoplastic agents that selectively kill dividing cells. adj., adj cytotox´ic.
antibody-dependent cell-mediated cytotoxicity (ADCC) (antibody-dependent cellular cytotoxicity) lysis of target cells coated with antibody by effector cells with cytolytic activity and specific immunoglobulin receptors called Fc receptors, including K cells, macrophages, and granulocytes. Lysis of the target cell is extracellular, requires direct cell-to-cell contact, and does not involve complement.
cell-mediated cytotoxicity destruction of a target cell by specific lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent (see antibody-dependent cell-mediated c.) or independent, as in certain cell-mediated hypersensitivity reactions.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē),
The quality or state of being cytotoxic.
Farlex Partner Medical Dictionary © Farlex 2012

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē)
The quality or state of being cytotoxic.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

cytotoxicity

The property of being able to cause damage to, or death of, cells.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē)
The qual-ity or state of being cytotoxic.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
The V79 cells were treated with DMSA/[Ag.sub.2]S QDs and free DMSA to determine the cytotoxicity of the QDs itself and the coating material over a wide range of concentrations between 0 and 2000 [micro]g/mL for 24 h.
Chemicals for which both in vivo acute oral toxicity data and in vitro cytotoxicity data were available were selected.
However, in terms of percent inhibition, at higher concentrations NM4 showed higher cytotoxicity than miltefosine (Table I; Fig.
Figures 7-10 shows, the in vitro cytotoxicity of pure hydrogel, silver, and gold nanocomposite hydrogels evaluated using MTT assay in fibroblast cell 3T3 cell line treated with various concentrations of composite hydrogels.
From the measurement of the formazan crystals absorbance, cell viability associated with cytotoxicity in MDCK C11 cells was evaluated (Figure 4).
The percent specific cytotoxicity of each compound was determined based on (1-OD experiments / OD positive controls) x100%.
After taking 10 [micro]L of cell culture for cytotoxicity testing, the remaining lymphocytes were cultivated in 5 mL RPMI 1640 (Invitrogen, Paisley, UK), adding 1 mL of fetal bovine serum (Gibco, Paisley, UK), 0.1 mL of phytohemagglutinin, 100 IU penicillin (Sigma, St.
The cytotoxicity was expressed as percent of viability with regard to untreated control wells, using mean [+ or -] standard deviation of two independent experiments.
For cytotoxicity experiments the cells were seeded on sterile cover glasses with a diameter of 12 mm at a density of 2 x [10.sup.4] cells/well in 24-well plate and incubated for 24 hours.
Following overnight incubation at 37[degrees]C in a 5% C[O.sub.2], 100 of fresh media containing plant extracts was added to the cells in the plates for cytotoxicity assay.
The results corresponding to the cytotoxicity test show slight differences in cell viability between 24 and 48 hrs of cell exposition to AgNPs.