Gell and Coombs classification of drug allergies (6) Type Mechanism Example Type 1 IgE antibodies mast cell/ Penicilin- basophil degranulation anaphylaxis Type 2 IgG against cell surface/ IgM-mediated cytotoxic reaction
Quinidine- hemolytic anemia Type 3 Immune complex Cephalexin- storage reaction serum disease Type 4 Delayed type Neomycine- cell-mediated reaction contact dermatitis Table 4.
released after 8 hours and cytotoxic reaction
of UMR106--osteoblast-like cells for all experimental GICs, Spearman's rank correlation coefficient were obtained.
Table 1 Type Description Method of Detection I An immediate reaction that can result Provocation test, skin in an anaphylactic reaction test, IgE RAST II Cytotoxic reaction
mediated by IgM and IgG serum test IgG antibody responses to host tissue III IgG and IgM antibodies form immune IgG serum test complexes with antigens in the blood IV Delayed reaction mediated by memory T Skin test, MELISA cells
We detected an unexpected Class II IgG complement-dependent cytotoxicity for all sera tested, enhanced by DTT treatment according to the ASHI scoring system (1 and 2 as negative, 4 as 30-49%, 6 as 50-79%, and 8 as 80-100% lysed lymphocytes (see Table 1)) and also in the B-cells negative control well (serum pool from donors which shows no cytotoxic reactions
in the lymphocytotoxicity test, BioRad, CA).
foreign body granulomatous reaction, inflammation and cytotoxic reactions
, Oxidative stress, DNA damage and carcinogenicity.
Regarding the cytotoxicity of UV pre-cured latex, only mild cytotoxic reactions
were observed after exposure to the undiluted extract of the UV prevulcanized surgical glove.
resulting from elevated amounts of NO can be direct and indirect.