cytotoxic drugs

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cytotoxic drugs

Drugs capable of damaging or killing cells. These can be used in the treatment of cancer because their effect is greatest on cells which are reproducing most rapidly. The cytotoxic drugs include alkylating agents, such as cyclophosphamide, melphalan and chlorambucil, that interfere with cell growth differentiation and function; cytotoxic antibiotics, such as dactinomycin, daunorubicin and doxorubicin, that bind to DNA blocking its transcription; antimetabolites, such as fluoruracil, cytarabine and mercaptopurine, that interfere with the action of folates; vinca alkaloids, such as vinblastine, vincristine and taxol, that block mitosis; and the TOPOISOMERASE 1 inhibitors, such as etoposide, anthracyclines and anthrapyrazoles, that interfere with nuclear enzymes required for DNA replication and the separation of daughter chromosomes.

Cytotoxic drugs

Drugs that function by destroying cells.
Mentioned in: Antirheumatic Drugs


having a deleterious effect upon cells.

cytotoxic antibody
see cytotoxic antibody.
cytotoxic drugs
generally refers to those used in chemotherapy of neoplasms, e.g. cyclophosphamide, vincristine, etc.
cytotoxic T lymphocyte
see T lymphocyte.
References in periodicals archive ?
Therefore, adequate containment strategies and proper classification of hazards are essential for the manufacture of highly potent active pharmaceutical ingredients and cytotoxic drugs.
Protective clothing must be worn by all personnel preparing cytotoxic drugs, cleaning cytotoxic preparation facilities, or cleaning cytotoxic spills.
Previously, conventional cytotoxic drugs have been used to treat breast cancer metastases and also in the adjuvant setting, but have not been found to be especially effective on bone metastases.
Thirty years ago, nurses working in oncology wards would complain of having constantly sore eyes and yellow hands from working with cytotoxic drugs.
In preclinical studies, OGX-427 has shown to significantly reduce levels of Hsp27, induce apoptosis in several cancer cell lines, has single agent anti-tumour activity, and acts as a chemosensitizer with several cytotoxic drugs, including docetaxel.
the cytotoxic drugs used in cancer treatment and their metabolites).
Pharmacokinetic interactions may be somewhat unpredictable, and increases in the plasma levels of these cytotoxic drugs may occur, particularly with inhibition of cytochrome P450 enzymes from antiretroviral drugs such a ritonavir.
It has been designed for use in trauma situations and the handling of cytotoxic drugs, and has been tested and certified for use in chemotherapy.
It is very important to utilize serum-stable linker systems when delivering potent, cytotoxic drugs to tumor cells via monoclonal antibodies.
Of particular interest to us, and emphasized in the patent, is the use of a B-cell specific antibody, such as our CD22 humanized antibody, for the therapy of non-Hodgkin's lymphoma, whereby a site-specific conjugation of cytotoxic drugs could be made with this antibody that internalizes into B-cells," she added.
Thus, when a tumour is detected the disease may already have begun to spread to other tissue sites (metastasis), in which case recourse often must be made to treatment by systemically administered cytotoxic drugs.

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