cytotoxic drugs


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cytotoxic drugs

Drugs capable of damaging or killing cells. These can be used in the treatment of cancer because their effect is greatest on cells which are reproducing most rapidly. The cytotoxic drugs include alkylating agents, such as cyclophosphamide, melphalan and chlorambucil, that interfere with cell growth differentiation and function; cytotoxic antibiotics, such as dactinomycin, daunorubicin and doxorubicin, that bind to DNA blocking its transcription; antimetabolites, such as fluoruracil, cytarabine and mercaptopurine, that interfere with the action of folates; vinca alkaloids, such as vinblastine, vincristine and taxol, that block mitosis; and the TOPOISOMERASE 1 inhibitors, such as etoposide, anthracyclines and anthrapyrazoles, that interfere with nuclear enzymes required for DNA replication and the separation of daughter chromosomes.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Cytotoxic drugs

Drugs that function by destroying cells.
Mentioned in: Antirheumatic Drugs
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Miltefosine was the most cytotoxic drug with an IC50 of 72.26 in PBLs and a consistently higher % inhibition through all the four studied concentrations.
The ability of the increased EGFR signaling to protect MCF-7(TamR) cells from the effects of a panel of cytotoxic drugs was carefully examined, and it was observed that increased levels of EGFR signaling offered cells no significant protection from any of the five drugs studied, and in the case of certain drugs (most clearly with paclitaxel, but also to a lesser extent with other drugs, including etoposide), high EGFR expressing tamoxifen-resistant cells were significantly sensitized to killing with these agents.
We did not advise any systemic chemotherapy with cytotoxic drugs due to expected high risk of profound toxicity, as the metabolizing potential for cytotoxic drugs in this patient is unknown.
It also has several promising preclinical projects that see NanoZolid combined with cytotoxic drugs and with immune-active substances, such as antibodies.
Uttar Pradesh, March 24 -- Site specific antibodies conjugated to cytotoxic drugs - the answer to cancer when they were first developed.
Using antibodies which selectively recognize cancer cells conjugated with appropriate cytotoxic drugs, ADCs (antibody-drug conjugates) allow highly cytotoxic molecules to be specifically released at the desired site of action, i.e.
RA is treated with painkillers and cytotoxic drugs to damp down the autoimmune process.
Over the last few years, there has been a rising demand for targeted therapies with high potency compounds such as high potency active pharmaceutical ingredients and certain cytotoxic drugs. Oncology appears to be the leading domain for these products and increased use in the treatment of certain cancer indications has gained much attention due to the low dosage requirements and lower side effects.
After identification of Aspergillus niger on culture, inquiries revealed no exposure to steroids, cytotoxic drugs, or irradiation, and workups for malignancy, human immunodeficiency virus infection, tuberculosis, and diabetes were negative.
They have also been tested against ASTM F739 99A for cytotoxic drugs with no breakthrough detected after 480 minutes for all drugs tested.
Health worker preparing cytotoxic drugs without adequate precautions have been shown to contaminate themselves and their work environment.
He said that Cancer was one of the fatal diseases which treated with cytotoxic drugs including Cisplating vomiting was one of the major adverse drug reaction of these drugs which has been the major reason of the patient non compliance and ultimately lead to refusal of curative treatment.

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