cytotoxic drug


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cytotoxic drug

any pharmacological compound that inhibits the proliferation of cells within the body. Such compounds as the alkylating agents and the antimetabolites designed to destroy cells (with a high growth fraction) are commonly used in chemotherapy. Cytotoxic agents have a potential for producing teratogenesis, mutagenesis, and carcinogenesis.

cytotoxic drug

Oncology An anticancer drug which acts by killing or preventing the cell division Adverse effects Damage to noncancerous tissues or organs with a high proportion of actively dividing cells–eg, BM, hair follicles, GI tract, thereby limiting the amount and frequency of drug administration. See Chemotherapy.
References in periodicals archive ?
Protective clothing must be worn by all personnel preparing cytotoxic drugs, cleaning cytotoxic preparation facilities, or cleaning cytotoxic spills.
designating a cytotoxic drug administration area, which only permits entry to authorised people.
GRN1005 is designed to deliver cytotoxic drug across the BBB and into tumors by exploiting a native mechanism by which essential substances, such as lipids and hormones, are actively transported into the brain through receptors.
GRN1005 is designed to deliver cytotoxic drug across the BBB and into tumors by exploiting a natural mechanism by which essential substances, such as lipids and hormones, are actively transported into the brain through receptors.
Table 29: Comparison of cytotoxic drug class sales ($m) in the BRIC countries, Australia and Canada, 2008 71
Further advances have been made by selecting cytotoxic drugs without drug resistance, by using peptide linkers instead of chemical moieties and by
The company's PSMA-ADC is a fully human monoclonal antibody to PSMA linked to a derivative of auristatin, a highly potent cytotoxic drug.
Contract notice: Supply of medical devices for the preparation of a cytotoxic drug and parenteral nutrition.
The monoclonal antibody portion binds PSMA with high affinity and specificity, thereby targeting the cytotoxic drug to cancer cells.
We did not advise any systemic chemotherapy with cytotoxic drugs due to expected high risk of profound toxicity, as the metabolizing potential for cytotoxic drugs in this patient is unknown.
It also has several promising preclinical projects that see NanoZolid combined with cytotoxic drugs and with immune-active substances, such as antibodies.
Contract notice: Delivery of medicinal products, antibiotics, medicinal products used in the programs drug, medical device for the administration of cytotoxic drugs and diet.

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