'While several new agents have been recently approved for AML, a backbone of cytotoxic chemotherapy
continues to be necessary for treatment with curative intent.
drugs disrupt the way cancer cells grow and divide, but they also affect normal cells.
The global trial evaluated once-daily TALZENNA compared to physician's choice standard chemotherapy in patients with an inherited BRCA1/2 mutation in triple-negative or HR+/HER2- LA or MBC who may have received up to three prior cytotoxic chemotherapy
regimens for their advanced disease.
ADCs are targeted cancer medicines that deliver cytotoxic chemotherapy
("payload") to cancer cells via a linker attached to a monoclonal antibody that binds to a specific target expressed on cancer cells.
Rolontisis a long-acting granulocyte colony-stimulating factor (G-CSF) being studied as a treatment for neutropenia in patients undergoing myelosuppressive cytotoxic chemotherapy
The results of that study, published in the Journal of Clinical Oncology (MN Polizzotto et al, JCO, 2016, 34, 4125-31), evaluated POMALYST in patients with Kaposi sarcoma, with or without HIV infection, many of whom had received prior cytotoxic chemotherapy
PATIENTS WITH MERKEL CELL carcinoma (MCC) treated with the immune checkpoint inhibitor pembrolizumab (Keytruda) had higher complete response rates, better progression-free survival, and longer overall survival than historical controls treated with cytotoxic chemotherapy
It's a different world now in metastatic melanoma because instead of the traditional cytotoxic chemotherapy
that not only kills cancer cells but also kills normal cells, we're stimulating the immune system to attack the cancer cells." The researchers worked with a total of 80 adults who received TVEC injections over the course of 3 years for the treatment of late-stage metastatic melanoma.
M2 EQUITYBITES-November 26, 2018-The Mundipharma network wins EC and CHMP approval for Pelmeg for reduction of neutropenia and febrile neutropenia during cytotoxic chemotherapy
Global Banking News-November 26, 2018-The Mundipharma network wins EC and CHMP approval for Pelmeg for reduction of neutropenia and febrile neutropenia during cytotoxic chemotherapy
However, Hrom said metastatic triple-negative breast cancer continues to be a challenging disease with a poor prognosis due to limited therapies other than standard cytotoxic chemotherapy
. Newer therapies such as PARP inhibitors may improve survival in this area, as well.