cytotoxic agent


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Related to cytotoxic agent: cytotoxic drugs, Cytotoxins

cytotoxic agent

A drug that destroys cells or prevents them from multiplying. Cytotoxic agents are used to treat cancers and severe immunological disorders, e.g., vasculitis, some forms of glomerulonephritis. An ideal agent would destroy proliferating cells without injuring the normal cells of the body.
See also: agent
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
An ideal ADC consists of a highly selective mAb for a tumor-associated antigen that has little or no expression on normal cells, a potent cytotoxic agent designed to induce target cell death after being internalized in the tumor cell and released and a chemical linker that is stable in circulation but releases the cytotoxic agent in target cells.
Bis-isatin hydrazones with novel linkers: synthesis and biological evaluation as cytotoxic agents. Eur.
After analysis of air sampling from surgical theater, serum samples and samples from hands; no cytotoxic agent was detected.
The company has patented the cytotoxic agent Disorazol Z in 35 countries, including the United States, Japan, Europe, China, Russia, Korea and Taiwan.
The synthesized compound can be used as a template for future development through modification and derivatization to design more potent and selective cytotoxic agent. Also the synthesized compound was also screened for in vitro antimicrobial activity by using the disc-diffusion method and determining the minimal inhibitory concentration (MIC) against Gram positive and Gram negative bacteria, and fungi.
Such drug loaded and navigated vehicles in order to enhance the selective uptake of the cytotoxic agent by the tumor cells and spare the normal cells, should consist of a multidimensional architecture (Figures 1 and 2).
Mitoxantrone (Novantrone[R]) is a cytotoxic agent used for MS as well as cancer treatment.
Titled "Bendamustine: A Novel Cytotoxic Agent for Hematologic Malignancies," it notes that bendamustine hydrochloride has a chemical structure containing alkylating nitrogen mustard, contributing to its cytotoxic properties.
In the case of U87 cells, the outer bark was the most potent cytotoxic agent (Figure 5).
The effect on the bone was not seen to any significant extent in a similar experiment with the cytotoxic agent, paclitaxel.
(In contrast, when a cytotoxic agent is ordered for an oncology indication, the facility requires that the most current protocol be printed from a provincial cancer website and placed in the patient's chart.