cytotoxic T-cell


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cytotoxic T-cell

a specialized T-cell which recognizes and destroys infected body cells during a cell-mediated immune response.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
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Spontaneously relapsing clonal, mucosal cytotoxic T-cell lymphoproliferative disorder: case report and review of the literature.
A small proportion of cases show rearrangements of the TCR genes (up to 27%), which probably represent neoplasms of cytotoxic T-cells [3, 6].
Villamor et al., "Clonal T-cell populations and increased risk for cytotoxic T-cell lymphomas in B-CLL patients: clinicopathologic observations and molecular analysis," American Journal of Surgical Pathology, vol.
Jones et al., "Allogeneic cytotoxic T-cell therapy for EBV-positive posttransplantation lymphoproliferative disease: results of a phase 2 multicenter clinical trial," Blood, vol.
Furthermore, in the early phases of BRAF/MEK inhibition, there is increased cytotoxic T-cell infiltration in tumor samples [87-89].
This edition has expanded discussion of pathogen and danger-associated molecular patterns and lymphocyte trafficking; a new section on dendritic cells and their role in antigen processing including cross-presentation; updated sections on B-Cell and NK receptors; the latest findings on T-cell subsets; new information on NK and cytotoxic T-cell killing mechanisms; and more on the effects of aging on immune responses.
Gajewski said that the vaccines most likely to succeed are those developed through a stepwise scientific approach, which involves methodical selection of antigens in combination with the adjuvants that produce the optimal cytotoxic T-cell response.
Influenza nucleoprotein-specific cytotoxic T-cell clones are protective in vivo.
Boosting the antigen-specific T-helper cell response is critical to getting strong, prompt humoral and cytotoxic T-cell response for complete and rapid control of infection.
The TAP-1 technology provides a general method for the augmentation of immune (cytotoxic T-cell) response against immune-resistant forms of metastatic cancer.
Researchers have shown that cocaine suppresses immune function in mice by decreasing phagocytosis, antibody function, and natural killer-cell and cytotoxic T-cell activity.
What we're spending substantial effort on right now is trying to formulate it in order to induce immune responses to all areas of the immune system, meaning helper T-cell responses, cytotoxic T-cell responses, and antibody responses, and also eliciting consistent and high-level responses in the majority of patients.

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